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Inbred Strains of Mice: ICR


No details. Maint. by Cri.


Inbr 29. Albino. Origin: BLU:Ha(ICR) outbred stock from the Institute of Cancer Research in 1958, to Arbor Scientific Co. Ltd., to UBC, Vancouver in 1977, followed by sib mating. Maint. by Bc.


Inbr: F43 +. Albino. Genet: A, B, c, P, rd+. Origin: Hauschka from `Swiss Webster' stock purchased from J. C. Landis in 1947.


Litter size 8.3 _ 0.13 with 30% preweaning mortality. High intrastrain aggression. Has been typed at several polymorphic loci (Hauschka and Mirand, 1973). Susceptible to colon carcinogenesis by 1,2-dimethylhydrazine (cf. 3/7) (Evans et al., 1977., 1977). High histamine release from peritoneal mast cells induced by compound 48/80, a calcium dependent histamine releaser (3/8) (Toda et al 1989). High histamine release from peritoneal mast cells induced by Ca2+ ionophore A23187 ( c.f. 7/8, contrast C57BL/6) (Toda et al 1989). Susceptible to the anaphylactic death following an intravenous injection of bovine serum albumin into primed mice (Lei et al, 1996).

Evans J. T., Shows T. B., Sproul E. E., Paolini N. S., Mittelman A., and Hauschka T. S. (1977) Genetics of colon carcinogenesis in mice treated with 1, 2-dimethylhydrazine. Cancer Res. 37, 134-136.

Hauschka T. S. and Mirand E. A. (1973) The `Breeder: HA (ICR)' Swiss mouse, a multipurpose stock selected for fecundity. Liss, In Perspectives in Cancer Research and Treatment (ed. Murphy, G.P.), Alan R.

Lei H. Y., Lee S. H., and Leir S. H. (1996) Antigen-induced anaphylactic death in mice. International Archives of Allergy and Immunology 109, 407-412.

Toda S., Kimura M., and Tohya K. (1989) Strain differences in histamine release from mouse peritoneal mast cells induced by compound 48/80 or A23187. Jikken Dobutsu - Experimental Animals 38, 135-137.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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