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Inbred Strains of Mice: ICGN


Inbr. F26 (Asano, 1993). Albino. Origin: Outbred ICR stock inbred by Ogura,Takano, Yamamoto and Asano, Dept. of Veterinary Sci. NIH, Japan. All animals develop glomerular nephritis (Ogura et al 1989, 1990, 1991a,b). Initially, mice develop hyproteinemia and hypoalbuminemia with a progressive rise in urinary protein. Later the concentrations of total cholesterol, triglyceride and betalipoprotein increase. Finally there is a rapid deterioration of renal function with high blood urea nitrogen and creatinine levels (Ogura et al, 1994).

Ogura A., Asano T., Matuda J., Nakagawa M., and Fukui M. (1989) Characteristics of mutant mice (ICGN) with spontaneous renal lesions: a new model for human nephrotic syndrome. Lab. Anim. 23, 169-174. \par

Ogura A., Asano T., Suzuki O., Yamamoto Y., Noguchi Y., Kawaguchi H., and Yamaguchi Y. (1994) Hereditary nephrotic syndrome with progression to renal failure in a mouse model (ICGN strain): Clinical study. Nephron 68, 239-244. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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