of Mice: HRS
Inbr. F79 (J). Albino, b,c,d.
Origin: Hairless (hr
from Crew to Carnochan to Heston to Chase, to E.L.Green 1952, to Les 1956,
to M.C.Green 1959, to J 1964. Maintained by mating +/hr
with hr/hr males.
Homozygous hairless mice lose their hair at about 10 days. The complete
hair is lost from the follicle. After a time a few thin fuzzy hairs grow
again, but are soon lost. These are exclusively guard hairs. There is
hyperkeratosis of the stratified epithelium and the upper part of the
hair canals. Hair club formation is abnormal and the lower part of the
follicles tends to separate from the upper part. The isolated lower parts
develop into cysts, which may become large and numerous (M. C. Green,
1966). About 45% of hrhr
mice develop leukaemia by 8-10 months
compared with only 1% in hr
/+ mice. Graft versus host assay shows
mice are immunologically hyporesponsive, which may
be associated with the high leukaemia incidence (I'Anson and Gasser, 1973
). Similarly, Heiniger et al
) found 70% leukaemia at 8 months
mice but only 20% in hr
/+. Difference thought
to be due to a functional immune deficiency. Large kidney/body weight
ratio (1/21) (Schlager, 1968
). High lymphocyte
phytohaemagglutinin response (13/43) (Heiniger
et al., 1975
H. J., Meier H., Kaliss N., Cherry M., Chen H. W., and Stoner R. D. (1974)
Hereditary immunodeficiency and leukemogenesis in HRS/J mice. Cancer
Res. 34, 201-211.
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
V. A. and Gasser D. L. (1973) Relationship between graft-vs-host reactivity
and possession of the high leukaemia genotype hr/hr. J. Immunol.
Schlager G. (1968)
Kidney weight in mice: strain differences and genetic determination. J.
Hered. 59, 171-174.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,