About   Help   FAQ
Inbred Strains of Mice: HR

HR/De

Inbr: F78 +. Pink-eyed dilute strain carrying hairless mutation. Genet: p, hr with forced heterozygosity. Inbred by Deringer from hr stock received from Carnochan in 1948.


Characteristics

Haemangioendotheliomas 19-33% (Heston, 1963). Skin papillomas in 3-9% of hairless animals at 18-22 weeks (Murphy, 1966). High incidence of haemangioendotheliomas (54-76%) in mice treated with 4-0- tolylazo-Otoluidine (Heston, 1963). Sensitive to chloroform toxicity (cf. 4/9) (Deringer et al., 1953., 1953). Type B reticulum-cell neoplasms at 20 weeks 12% (haired) and 8% (hairless) (Dunn and Deringer, 1968).


Deringer M. K., Dunn T. B., and Heston W. E. (1953) Results of exposure of strain C3H mice to chloroform. Proc. Soc. Exp. Biol. Med. 83, 474-479. \par

Dunn T. B. and Deringer M. K. (1968) Reticulum cell neoplasm, type B, or `Hodgkin's-like lesion' of the mouse. J. Natl. Cancer Inst. 40, 771-821. \par

Heston W. E. (1963) Genetics of neoplasia, in Methodology in mammalian genetics (Burdette W. J., ed), pp. 247-268. Holden-Day, San Francisco. \par

Murphy E. D. (1966) Characteristic tumors, in Biology of the laboratory mouse, 2nd. ed. (Green E. L., ed), pp. 521-562. McGraw-Hill, New York. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/19/2017
MGI 6.10
The Jackson Laboratory