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Inbred Strains of Mice: HR


Inbr: F78 +. Pink-eyed dilute strain carrying hairless mutation. Genet: p, hr with forced heterozygosity. Inbred by Deringer from hr stock received from Carnochan in 1948.


Haemangioendotheliomas 19-33% (Heston, 1963). Skin papillomas in 3-9% of hairless animals at 18-22 weeks (Murphy, 1966). High incidence of haemangioendotheliomas (54-76%) in mice treated with 4-0- tolylazo-Otoluidine (Heston, 1963). Sensitive to chloroform toxicity (cf. 4/9) (Deringer et al., 1953., 1953). Type B reticulum-cell neoplasms at 20 weeks 12% (haired) and 8% (hairless) (Dunn and Deringer, 1968).

Deringer M. K., Dunn T. B., and Heston W. E. (1953) Results of exposure of strain C3H mice to chloroform. Proc. Soc. Exp. Biol. Med. 83, 474-479.

Dunn T. B. and Deringer M. K. (1968) Reticulum cell neoplasm, type B, or `Hodgkin's-like lesion' of the mouse. J. Natl. Cancer Inst. 40, 771-821.

Heston W. E. (1963) Genetics of neoplasia, in Methodology in mammalian genetics (Burdette W. J., ed), pp. 247-268. Holden-Day, San Francisco.

Murphy E. D. (1966) Characteristic tumors, in Biology of the laboratory mouse, 2nd. ed. (Green E. L., ed), pp. 521-562. McGraw-Hill, New York.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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