of Mice: HLG
Inbr. >30 (1993). Albino, A,B,c,D.
An inbred strain in 1938 at
the Inst. of Radiology, Univ. of Freiburg. To Heiligernberg in 1945, then
returned to Freiburg in 1950. In 1982 to Inst. of Radiation Biology, University
Clinic Essen, Germany. Brother x sister mating started in 1985 by Dr.
D. Buttner. Defined at 22 biochemical loci. High fat content, especially
in older females. Good breeding performance. Used because of its synchrony
in early embryonal development (Molls et al
). High incidence of spontaneous and radiation-induced congenital
malformations (Pampfer and Streffer 1988
High incidence of gastroschisis, a herniation of the abdominal viscera
with umbilical ring disruption and intestinal evisceration following X-ray
exposure of the zygotes (Hillebrandt
et al, 1996
S., Streffer C., and Muller W. U. (1996) Genetic analysis of the cause
of gastroschisis in the HLG mouse strain. Mutation Research-Fundamental
and Molecular Mechanisms of Mutagenesis 372, 43-51.
Zamboglu N., and Streffer C. (1983) A comparison of the cell kinetics
of preimplantation mouse embryos from two different mouse strains. Cell
Tissue Kinet. 16, 277-283.
S. and Streffer C. (1988) Prenatal death and malformations after irradiation
of mouse zygotes with neutrons or X-rays. Teratology 37,
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,