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Inbred Strains of Mice: GT


Inbr (Le) 28. Breeders are agouti:A,gt/+;gt/gt are light grey with white belly spot and have tremors like myelin deficient mice. Origin: Developed by Lane. gt mutation arose in strain HYIII/Le in 1977 at F55. One outcross to C3HeB/FeJ x C57BL/6-AwJ F1, then bxs. Has a spontaneous spongiform encephalopathy whose expression is determined by the interaction of genetic factors and an unconventional unrecognised transmissible agent (Sidman et al 1985). The strain is maintained only as frozen embryos by Dr. T Cunliffe-Beamer.

Sidman R. L., Kinney H. C., and Sweet H. O. (1985) Transmissable spongiform encephalopathy in the gray tremor mutant mouse. Proc. Natl. Acad. Sci. USA 82, 253-257. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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