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Inbred Strains of Mice: GRS


Inbr (A) 101. Albino a,c. Origin:Formerly called GR/A. Muhlbock 1965 from outbred mice obtained from Grumbach in Zurich.


Breeding females have a high incidence of mammary tumours which are highly hormone-responsive. Carries a mammary tumour agent different from MTI, transmitted by milk and gametes, which is not eliminated by foster nursing. Hormone-dependent tumours are also produced in GRS x RIII F1 hybrids (Muhlbock, 1965; van Nie and Thung, 1965; Brcand and Daehnfeldt, 1973). High incidence of hepatomas in mice treated with normal horse serum or horse-anti-mouse antilymphocyte serum (Den Engelese et al., 1976., 1976). Leukosis 11% (Hilgers and Galesloot, 1973). Susceptibility to mammary tumour induction with progesterone and oestrone in ovariectomised mice may be due to a single gene, although linkage with eighteen marker loci could not be established (van Nie and Hilgers, 1976). Resistant to the development of uterine tumours following treatment with DMBA at 4-weeks of age (cf 3/6) (Tsubura et al, 1993).

Brcand P. and Daehnfeldt J. L. (1973) Enzyme patterns of glucose catabolism in hormone-dependent and independent mammary tumours of GR mice. Eur. J. Cancer 9, 763-770.

Den Engelese L., Misdorp W., and Emmelot P. (1976) Hepatomas in GRS/A male mice treated with horse serum or horse anti-mouse antilymphocyte serum. Eur. J. Cancer 12, 101-106.

Hilgers J. and Galesloot J. (1973) Genetic control of MuLV-gs expression in crosses between high and low leukemia incidence strains. Int. J. Cancer 11, 780-793.

Tsubura A., Senzaki H., Oyaizu T., Fujita Y., and Morii S. (1993) Strain differences in neoplastic response to DMBA-induced uterine vascular tumors in mice. International Journal of Oncology 2, 927-930.

van Nie R. and Thung P. J. (1965) Responsiveness of mouse mammary tumours to pregnancy. Eur. J. Cancer 1, 41-50.

van Nie R. and Hilgers J. (1976) Genetic analysis of mammary tumor induction and expression of mammary tumor virus antigen in hormone- treated ovariectomized GR mice. J. Natl. Cancer Inst. 56, 27-32.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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