of Mice: FVB
Inbr. F38. Albino,A,B,c,D,P
. Origin: Outbred N:GP (NIH General
Purpose) Swiss mice established at the National Institutes of Health in
1935. In 1966 two strains (HSFS/N and HSFR/N) were selected for sensitivity
and resistance, respectively, to challenge with histamine following pertussis
vaccination. In the early 1970s a group of mice at the eighth inbred generation
of HSFS/N were found to carry the Fv1b
allele for sensitivity to the B strain of Friend leukaemia virus. Homozygous
mice were then inbred as strain FVB, without further selection for histamine
sensitivity (Taketo et al 1991
(NIH) to Amsterdam, 1978.
Strain is useful for the production of transgenic mice on a fully inbred
genetic background. They have a vigorous reproductive performance with
large litters. Fertilized eggs contain large and prominant pronuclei which
facilitate the microinjection of DNA, and following injection survive
as well as C57BL/6 x SJL F1 hybrids, and much better than pure-line C57BL/6
(Taketo et al 1991
). The strain has been
typed at at least 44 marker loci on 15 chromosomes. Relatively insensitive
to the initiation of papillomas following initiation by 7,12-dimethylbenz(a)anthracene
and promotion with 12-o-tetradecanoylphorbol-13-acetate (TPA), but a high
proportion progress to carcinomas (Hennings
et al, 1993
). A new strain 129-derived embryonic stem cell line, H3.
gives good levels of germ-line transmission in chimeras involving FVB
(Kim et al, 1996
60% survival to 24 months of age in both sexes with 55% and 66% gross
tumour incidence in males and females, respectively at that time. Most
common tumour types were lung alveolar-bronchiolar, hepatocellular, subcutis
neural crest and Harderian gland adenomas in males and lung, pituitary,
ovarian, lymphomas, histiocytic sarcomas, Harderian gland adenomas and
pheochromocytomas in females (Mahler et al,
1996). Maint. by N, A, J.
H., Glick A. B., Lowry D. T., Krsmanovic L. S., Sly L. M., and Yuspa S.
H. (1993) FVB/N mice: An inbred strain sensitive to the chemical induction
of squamous cell carcinomas in the skin. Carcinogenesis 14,
Kim D., Park
D. H., Kang N. G., Namkoong Y., and Shin H. S. (1996) A new embryonic
stem-cell line with germ-line competence in the FVB/N background. Molecules
and Cells 6, 577-581.
J. F., Stokes W., Mann P. C., Takaoka M., and Maronpot R. R. (1996) Spontaneous
lesions in aging FVB/N mice. Toxicologic Pathology 24,
M., Schroeder A. C., Mobraaten L. E., Gunning K. B., Hanten G., Fox R.
R., Roderick T. H., Stewart C. L., Lilly F., Hansen C. T., and Overbeek
P. A. (1991) FVB/N: An inbred mouse strain preferable for transgenic analyses.
Proc. Natl. Acad. Sci. USA 88, 2065-2069.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,