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Inbred Strains of Mice: EL


Inbr (Yok) 84. Albino. c. Origin K.Imaizumi, El (epilepsy) mutation in non-inbred albino mice in 1954.


Epilepsy-like behaviour which can be induced by Megamide (Nakano et al, 1996). Phenobarbital suppresses the seizures dose-dependently, but zonisamide is ineffective (Nagatomo et al, 1996a). Seizure susceptibility may be due to a reduced number of nitric oxide-producing cells in the hippocampal area (Nagatomo et al, 1996b) Maint. by Yok.

Nagatomo I., Akasaki Y., Kuchiiwa S., Nakagawa S., and Takigawa M. (1996a) Sparse distribution of NADPH diaphorase neurons in the hippocampal-formation of the inbred mutant strain EL mouse. Brain Res. 730, 223-226. \par

Nagatomo I., Akasaki Y., Nagase F., Nomaguchi M., and Takigawa M. (1996b) Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse. Brain Res. 731, 190-198. \par

Nakano H., Saito K., and Suzuki K. (1996) Clinico-ECoG correlate of megimide-induced epileptic seizures in epilepsy-prone EL and its mother strain nonepileptic ddY mice. Physiol. Behav. 60, 809-816. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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