of Mice: DW
Inbr: F110 (J). Grey. Genet: a, ln.
Carries dwarf (dw)
with forced heterozygosity. dw
mutation arose in a stock of silver
mice obtained by Snell from an English fancier before 1929. Established
by Jackson Laboratory in 1966 from stock supplied by Lane.
The dwarf mutation causes a reduction in acidophils and thyrotrophin-producing
cells of the anterior pituitary. Mutant mice have a variety of anatomical,
cytological and physiological defects due to deficiency of anterior pituitary
hormone, including reduced growth and organ development and infertility.
Pituitary homografts or injections of growth hormone and/or prolactin
partially reverse some of these defects. Dwarf mice are almost tumour-free,
whereas their normal litter mates have a high incidence of a range of
tumours. However, dwarf mice also have a shorter life-span. Deficiencies
of RNA metabolism in the liver have been noted (Chen
et al., 1972a
, 1972a). Dwarf DW mice have a lower expression of group-specific
antigen to endogenous C-type
RNA tumour virus than normal litter
mates, which have 45-61% incidence of reticulum cell sarcoma (Chen et al., 1972b
, 1972b). A complete bibliography of
the strain from 1967 to 1973 has been given by
The effects of prolactin on activity of 17-beta-hydroxysteroid dehydrogenase
has been studied by Musto et al
W., Hamer D. H., Heiniger H. J., and Meier H. (1972a) Stimulation of hepatic
RNA synthesis in dwarf mice by ovine prolactin. Biochim. Biophys.
Acta 287, 90-97.
W., Meier H., Heiniger H. J., and Huebner R. J. (1972b) Tumorigenesis
in strain DW/J mice and induction by prolactin of the group-specific antigen
of endogenous C-type RNA tumour virus. J. Natl. Cancer Inst.
Hafiez A. A., and Bartke A. (1972) Prolactin increases 17 - hydroxysteroid
dehydrogenase activity in the testis. Endocrinol. 91,
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,