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Inbred Strains of Mice: DD


Inbr (A) 91. Albino: A,B,c,S. Origin: From noninbred ddN stock of Cen.Lab. Exp. Animals, Osaka University 1956, to Heston 1957 (Heston et al 1964), to Nara 1959.


Mammary tumours 84% at 7.7 months in DD, 4% at 20 months in DDfC57BL and 91% in DDfC3H at 6.7 months (Heston and Vlahakis, 1971). High serum haptoglobin level (2/11) (Peacock et al., 1967., 1967). High erythrocyte catalase (2/18) (Hoffman and Rechcigl, 1971). Host for transplantable androgen-dependent mouse mammary carcinoma SS-115, which only grows in intact males (Bruchovsky and Meakin, 1973). Develop keratinized nodules and squamous cell tumours when given urethan in the drinking water (Imai et al 1984). Low spontaneous locomotor activity (1/9) (Nikulina et al 1991).Carries an incomplete proviral genome of endogenous mammary tumour virus (MMTV) on the Y chromosome (c.f. 4/10) (Nishikawa et al 1991). Clonidene failed to produce an aggressive behavioural response (cf 3/9) (Nikulina and Klimek, 1993).

Bruchovsky N. and Meakin J. W. (1973) The metabolism and binding of testosterone in androgen-dependent and autonomous transplantable mouse mammary tumors. Cancer Res. 33, 1689-1695.

Heston W. E., Vlahakis G., and Tsubura Y. (1964) Strain DD, a new high mammary tumor strain, and comparison of DD with strain C3H. J. Natl. Cancer Inst. 32, 237-251.

Heston W. E. and Vlahakis G. (1971) Mammary tumours, plaques and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumour virus. Int. J. Cancer 7, 141-148.

Hoffman H. A. and Rechcigl M. Jr. (1971) Erythrocyte catalase in inbred mice. Enzyme 12, 219-225.

Imai S., Tsubura Y., and Hilgers J. (1984) Urethan-induced mammary tumorigenesis in a murine mammary tumor virus (MuMTV)-positive mouse strain: evidence for a keratinized nodule as an MmMTV-negative precursor lesion for squamous cell tumors. J. Natl. Cancer Inst. 73, 935-941.

Nikulina E. M., Skrinskaya J. A., and Popova N. K. (1991) Role of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test. Psychopharmacology 105, 525-529.

Nikulina E. M. and Klimek V. (1993) Strain differences in clonidine-induced aggressiveness in mice and its interaction with the dopamine system. Pharmacol. Biochem. Behav. 44, 821-825.

Nishikawa R., Okumoto M., Iwai M., Iwai Y., Takamori Y., Imai S., and Hilgers J. (1991) Incomplete proviral genome of mouse mammary tumour virus is present on chromosome Y of NIH Swiss and some genetically related mouse strains. Lab. Anim. 25, 4-8.

Peacock A. C., Gelderman A. H., Ragland R. H., and Hoffman H. A. (1967) Haptoglobin levels in serum of various strains of mice. Science 158, 1703-1704.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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