of Mice: DC
Inbr (Le) 100. Agouti, +. Origin: mutation to dancer Dc
in an obese stock outcrossed to a BALB/c x C3H/He hybrid in 1956. One
cross to C3H/HeJ, then inbred. Heterozygotes exhibit circling and head
tossing behaviour but are not deaf. Homozygotes die at birth with cleft
lip and cleft palate. A neurological mutation "scrambler" appeared in
1991. Homozygotes have unstable gait, with phenotype and pathology resembling
reeler (Sweet et al, 1996
). Maint. by Le.
O., Bronson R. T., Johnson K. R., Cook S. A., and Davisson M. T. (1996)
Scrambler, a new neurological mutation of the mouse with abnormalities
of neuronal migration. Mamm. Genome 7, 798-802.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,