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Inbred Strains of Mice: DC


Inbr (Le) 100. Agouti, +. Origin: mutation to dancer Dc arose in an obese stock outcrossed to a BALB/c x C3H/He hybrid in 1956. One cross to C3H/HeJ, then inbred. Heterozygotes exhibit circling and head tossing behaviour but are not deaf. Homozygotes die at birth with cleft lip and cleft palate. A neurological mutation "scrambler" appeared in 1991. Homozygotes have unstable gait, with phenotype and pathology resembling reeler (Sweet et al, 1996). Maint. by Le.

Sweet H. O., Bronson R. T., Johnson K. R., Cook S. A., and Davisson M. T. (1996) Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm. Genome 7, 798-802. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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