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Inbred Strains of Mice: CWD


Inbr (Le) 53. Non-agouti dilute: a,d,cw (curly-whiskers). Origin: cw arose in CBA/Cbi at Chester Beatty Res. Inst. To Harwell. Stock T11H from A.G.Searle to J in 1971. Crossed to B6C3Fe-a/a F1 then to DBA/2, then inbred.


Like AKR, HRS and C58, each of three CWD lymphomas produced infectious xenotropic murine leukemia virus related to endogenous xenotropic provirus Bxv1 (Massey et al 1990). However, in a later study the majority of CWD tumours contained recombinant viruses which lacked Bxv1 specific sequences (Massey et al, 1994).

Maint. by Le.

CXA-1 (reserved symbol)

Massey A. C., Coppola M. A., and Thomas C. Y. (1990) Origin of pathogenic determinants of recombinant murine leukemia viruses: analysis of Bxv-1-related xenotropic viruses from CWD mice. J. Virol. 64, 5491-5499. \par

Massey A. C., Lawrenz-Smith S. C., Innes D. J., and Thomas C. Y. (1994) Origins of enhancer sequences of recombinant murine leukemia viruses from spontaneous B- and T-cell lymphomas of CWD mice. Journal of Virology 68, 3773-3783. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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