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Inbred Strains of Mice: CAT


Inbr. ?+26 (Lac). Albino c,CatFr . Origin: CatFr arose in strain A. Apparently outcrossed to unknown stock, then inbred by Muggleton-Harris. (Muggleton-Harris et al 1987). All mice have bilateral cateracts. The lens abnormality begins to form before 14 days of interuterine life. Selective loss of a family of gene transcripts for specific crystallin synthesis has been reported (Garber et al 1985). Maint. by Muggleton-Harris.

Garber A. T., Winkler C., Shringhara T., King C. R., Inana G., Piatigorsky J., and Gold R. M. (1985) Selective loss of a family of gene transcripts in a hereditary murine cataract. Science 227, 74-77. \par

Muggleton-Harris A. L., Festing M. F. W., and Hall M. (1987) A gene location for the inheritance of the Cataract Fraser (CatFr) mouse congenital cataract. Genet. Res. 49, 235-238. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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