Inbred Strains
of Mice: CAST
Inbr ?+34 (1989). Origin: same as CASA. Resistant to flavivirus, unlike
most laboratory mice except C3H.RV (
Sangster
et al 1993). Low retinal ganglion cell number (2/24) (
Williams et al, 1996). Used as a tester strain in a novel
strategy for mapping new mutations in laboratory mice using simple sequence
repeats (SSR) with DNA pools from mutant and wild-type F2 progeny. A set
of 39 SSRs is expected to screen 94% of the autosomal genome in crosses
with laboratory strains (
Taylor et al, 1994).
Sangster
M. Y., Heliams D. B., MacKenzie J. S., and Shellam G. R. (1993) Genetic
studies of flavivirus resistance in inbred strains derived from wild mice:
evidence for a new resistance allele at the flavivirus resistance locus
(Flv). J. Virol. 67, 340-347.
Taylor
B. A., Navin A., and Phillips S. J. (1994) PCR-amplification of simple
sequence repeat variants from pooled DNA samples for rapidly mapping new
mutations of the mouse. Genomics 21, 626-632.
Williams
R. W., Strom R. C., Rice D. S., and Goldowitz D. (1996) Genetic and environmental-control
of variation in retinal ganglion-cell number in mice. Journal of Neuroscience
16, 7193-7205.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK