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Inbred Strains of Mice: CAST


Inbr ?+34 (1989). Origin: same as CASA. Resistant to flavivirus, unlike most laboratory mice except C3H.RV (Sangster et al 1993). Low retinal ganglion cell number (2/24) (Williams et al, 1996). Used as a tester strain in a novel strategy for mapping new mutations in laboratory mice using simple sequence repeats (SSR) with DNA pools from mutant and wild-type F2 progeny. A set of 39 SSRs is expected to screen 94% of the autosomal genome in crosses with laboratory strains (Taylor et al, 1994).

Sangster M. Y., Heliams D. B., MacKenzie J. S., and Shellam G. R. (1993) Genetic studies of flavivirus resistance in inbred strains derived from wild mice: evidence for a new resistance allele at the flavivirus resistance locus (Flv). J. Virol. 67, 340-347.

Taylor B. A., Navin A., and Phillips S. J. (1994) PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse. Genomics 21, 626-632.

Williams R. W., Strom R. C., Rice D. S., and Goldowitz D. (1996) Genetic and environmental-control of variation in retinal ganglion-cell number in mice. Journal of Neuroscience 16, 7193-7205.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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