of Mice: C57BR
Inbr (J) 178. Brown: a,b.
Origin: Little in 1921 from the same
cross that gave rise to C57BL, C57BR/a and C57L. Black and brown substrains
were separated in the first generation. Substrain cd was established at
F13 from a cross between two brown substrains, one of which had previously
given rise to C57BR/a. To Heston 1938, to J 1947 at F66. Maint. by J.
High intrastrain aggression (1/14), high open-field activity (1/14), high
spontaneous bar-pressing (2/14) and low social grooming during aggressive
encounters (11/14) (Southwick and Clark,
, 1968). High open-field activity (1/15) (Thompson,
). High shock-avoidance learning (1/9) (Bovet
et al., 1966
., 1966), (2/9) (Bovet et al.,
., 1969). High alcohol preference (3/18) (Rodgers,
Life-span and spontaneous disease
Primary lung tumours 3% in males, 1%,, in breeding females and zero in
virgin females, lymphatic leukaemia less than 1% (Hoag,
). Pituitary tumours 33% in old breeding females (Murphy,
Long life-span in conventional conditions (20/22 = 703 days in males and
19/22 = 694 days in females), hepatomas 25% in males (Storer,
1966). Life-span intermediate in both sexes in SPF fostered conditions
(10/17 = 577 days in males, 9/17 = 660 days in females) (Festing and Blackmore, 1971).
Normal physiology and biochemistry
Low systolic blood pressure (16/19) (Schlager
and Weibust, 1967
). High mean heart rate (2/7) but low mean heart
rate adaptation (6/7) (Blizard and Welty,
). High metabolic rate (5/18) (Storer, 1967
High cell turnover as estimated by clearance of DNA-bound radioactivity
(1/17) (Heiniger et al., 1972
Low plasma cholinesterase activity (20/22 in males, 16/22 in females)
(Angel et al., 1967
., 1967). High hypoxanthene-guanine
phosphoribosyl transferase in thalamus (2/7) (Suran
). Low brain L
-glutamic acid decarboxylase (GAD) (6/7)
and acetylcholinesterase activity (6/7), but high monoamine oxidase activity
(2/7) (Tunnicliff et al., 1973
Low percentage of the time spent sleeping (6/6), with low percentage of
slow-wave sleep (6/6) and high percentage of paradoxical sleep (1/6) (Valatx and Bugat, 1974). High proportion
of paradoxical (REM) sleep (1/7) (Pagel et
al., 1973., 1973).
Low sensitivity to thyrotropin (21/21) (Levy
et al., 1965., 1965). Low glucose-6-phosphate dehydrogenase activity
(15/16) (Hutton, 1971). Low hepatic delta-aminolaevulinic
acid synthetase activity after DDC treatment (15/15) (Gross and Hutton, 1971). High hepatic nicotinamide N-methyltransferase
levels (1/10) (Scheller et al, 1996)
Susceptible to the induction of atherosclerosis and develop large lesions
with many foam cells on a high-fat, high-cholesterol diet (13/13) (Roberts and Thompson, 1976).
Low brain weight (24/25) (Roderick et al.,
., 1973). High total leukocyte count (5/18), high haematocrit
(2/18), high mean corpuscular volume (3/18) and high haemoglobin (3/18)
(Russell et al., 1951
Nicotine decreases shock-avoidance learning (9/9) (Bovet et al., 1966
., 1966). Susceptible to tumour induction
by 3-methylcholanthrene (4/12) (Whitmire
et al., 1971
., 1971). Sensitive to insulin (1/9) and histamine (1/9)
). Resistant to hyperbaric oxygen
(18/18) with few central nervous system manifestations (Hill et al., 1968
i0 1968). Resistant to X-irradiation as
judged by the LD50
and Storer, 1969
), (2/9) (Storer, 1966
Resistant to chloroform toxicity (cf. 5/9) (Deringer
et al., 1953
., 1953). Sensitive (eosinophil response) to cortisone
acetate (cf. 3/6) (Wragg and Speirs, 1952
Highly susceptible to the induction of liver tumours by N,N-diethylnitrosamine.
At 50 weeks of age mean tumour multiplicity following a single dose of
DEN given at 12 days of age was 28_13 tumours compared with only 1.4 and
0.5 in C3H and C57BL/6, respectively. Ovariectomy increased tumour multiplicity
(Poole and Drinkwater, 1996
High lymphocyte phytohaemagglutinin response (7/43) (Heiniger et al., 1975
., 1975). Serum antinuclear factor
in 51% of animals (1/17) (Barnes and Tuffrey,
). Discriminator between `H' and `L' sheep erythrocytes (cf. 12/18)
(McCarthy and Dutton, 1975
have a low agglutinability (cf. 11/25) (Rubinstein
et al., 1974
Resistant to polyoma virus-induced tumours due to a resistance gene Pyvr
which did not recombine with Mtv-7.
can be overcome by irradiation, indicating an immunological basis (Lukacher et al, 1995
). Resistant to Mycoplasma
infection (cf 4/16) (Cartner
et al, 1996
Intermediate breeding performance (12/25), colony output 0.98 young/female/week,
litter size at weaning high at 6.5 (5/25) (Festing 1976a). Poor breeding
performance (24/24) (Hansen et al., 1973
1973). High ratio of females at birth (2/11) (Cook
and Vlcek, 1961
High degree of genetic distinctiveness (6/27) (Taylor,
). Recommended host for transplantable pituitary tumour BW8685
(Kaliss, 1972). High incidence of spontaneous `deviants' (possible mutations)
(1/21) (Schlager and Dickie, 1967
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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,