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Inbred Strains of Mice: C3HA


Inbr (Y) 102. Agouti:+ Origin: Pogosianz, C3H female x A male, followed by sib mating.


Originally 30% mammary tumours, but has declined. Susceptible to hepatic carcinogens. Treatment with 1,2-dimethylhydrazine resulted in 59% of mice developing hemorrhagic ovatian lesions but no unterine sarcome. The latter could be induced by DMH and estradiol dipropionate (Tutusov et al, 1994).

Clonidene failed to produce an aggressive behavioural response (cf 3/9) (Nikulina and Klimek, 1993).

Maint. by Y.

Nikulina E. M. and Klimek V. (1993) Strain differences in clonidine-induced aggressiveness in mice and its interaction with the dopamine system. Pharmacol. Biochem. Behav. 44, 821-825. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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