of Mice: C3H
Inbr: F130 to F170 depending on substrain. Agouti. Genet: +, rd
Developed by Strong 1920 from a cross of Bagg albino with DBA male (see
CBA) with selection for a high incidence of mammary tumours. Now among
the most widely used of all mouse strains. Most substrains have a good
reproductive performance. Unfostered substrains (which are now relatively
rare since 'SPF' animals have become popular) have a high incidence of
mammary tumours (usually > 90% at one year) caused by a virus which is
passed from mother to offspring through the milk. Fostering of the young
or transfer of fertilised ova to a mammary tumour virus-free strain eliminates
the virus, and substantially reduces the incidence of mammary tumours.
Note that all `SPF' stock will be free of this virus.
The unfostered substrains are widely used in cancer research for the sake
of their mammary tumours. Fostered stock are widely used as a general-purpose
strain which is readily available and well known. The strain should be
used with care in behavioural studies, since it carries the rd (retinal
degeneration) gene and is blind after about 6 weeks.
Some substrain differences are large, and can not be accounted for solely
on the basis of mutation, and must be ascribed either to substantial residual
heterozygosity or genetic contamination (McLaren
and Tait, 1969), though C3H/HeJ is known to differ from C3H/He as
a result of a mutation at the lps (lipopolysaccharide) locus.
The following major substrains are recognised:
Strong to Bittner 1931, to Kirschbaum 1952. Has 83% mammary tumours in
unfostered breeders. Low leukaemia.
Origin not known, but has a very high incidence of lymphatic leukaemia
(over 90%) (Fuchs, 1962
This substrain was passed to Heston in 1941,and is now the most widely
distributed of all. Non-fostered substrains have more than 90% mammary
tumours by about 11 months. Fostered substrains have a high incidence
of hepatomas (Festing and Blackmore, 1971
Heston, to Jackson Laboratory in 1947, and now widely distributed. Has
poor immune response to endotoxic lipopolysaccharide due to a B-cell deficit
(Rosenstreich and Glode, 1975; Coutinho, 1976
A substrain developed by transfer of fertilised ova to strain C57BL by
Deringer. This substrain lacks the mammary tumour virus and therefore
has a lower incidence of mammary tumours (4% in virgin females and 55%
in breeding females and 74% in force-bred females) (Deringer,
Inbr. N10F12 (1993). The a allele transferred from C57BL/6J. Now used
to create a B6C3Fe-a/a non-agouti hybrid as a coat colour marker for stocks
maintained by ovarian transfer.
C3HeB/Fe (syn: TC3H)
Developed by Fekete in 1948 by transfer of fertilized ova of C3H/HeJ to
C57BL/6. Lacks mammary tumour virus.
`Mahogany' coat colour mutation occurred spontaneously in C3H/He stock
held at Laboratory Animals Centre, Carshalton, in 1967. The strain has
been propagated because authenticity can be guaranteed by the colour of
Congenic line developed by backcrossing the Avy
to the C3H background. Has an exceptionally high mammary tumour incidence,
virtually 100% at 7-8 months. The fostered substrain C3H-Avy
fB has a 90% incidence of mammary tumours transmitted by either
parent (Vlahakis et al., 1970., 1970).
C3H.PRI-Flvr (formerly C3H.RV ) and
Congenic line resistant to flavivirus (arbovirus) infection, developed
by Groschel and Koprowski (1965) by
backcrossing the resistance gene from PRI to C3H, and by Shallam by backcrossing
the resistance gene from wild M.m. domesticus to C3H.
Low intrastrain aggression (10/14) (Southwick
and Clark, 1966
). Long latency to emerge from home-cage (6/7), low
rearing (7/7), long latency to cross barrier in open-field (6/7), low
hole-in-the-wall entries (6/7) and low Y-maze exploration (7/7) (McClearn et al., 1970
., 1970). Low open-field activity
(13/13) (Bruell, 1964
). Low open-field defaecation
(5/5) (Bruell, 1969
). High food drive (3/15)
), but poor performance in
food-seeking task (5/6) (Henderson, 1970
Short time of immobility in a forced swimming test (9/9) (Nikulina et al 1991
Low shock-avoidance learning (8/9) (Bovet et
al., 1966., 1966, 1969). Good short- term but poor long-term memory
in contrast with DBA/2 (Bovet et al., 1969.,
1969). Good T-maze learning (1/6) (Stasik, 1970).
Poor water-escape learning (6/6) (Festing, 1973b). Low radial-arm maze
learning (3/3) (Ammassari-Teule et
al, 1993). High social grooming score during aggressive encounters
(3/14) (Southwick and Clark, 1968).
Carries the retinal degeneration gene and is capable of pattern discrimination
up to 40 days, and brightness discrimination to at least 100 days (Nagy and Misanin, 1970).
Life-span and spontaneous disease
Almost 100% of mammary tumours in females of unfostered substrains (Heston, 1963). Mammary adenocarcinomas in unfostered
substrains less than 1% in males, 95% in breeding and 88% in virgin females.
Lymphatic leukaemia zero incidence (Hoag, 1963).
Mammary tumours 100% at 6.8 months in C3H-Avy
, 90% in C3H- Avy fC57BL at 15.3
months. Mammary tumours 40% at 18.8 months in C3HfC57BL, but 99% at 7.2
months in unfostered C3H (Heston and Vlahakis,
1971). Mammary tumours 37% at 2 years in fostered substrain (Bentvelzen et al., 1970., 1970). Median latent period to
develop mammary tumours in unfostered substrains ranged from 276 to 566
days, depending on breeding status and environmental stress (Riley,
1975). A high proportion of the mammary tumours are of the acinar
type (2/7) (Tengbergen, 1970). Incidence
of mammary tumours reduced by bromocriptine and interferon Stravoravdi
et al, 1993).
Hepatomas 72-91% in males at 14 months, 59% in virgin females, 30-38% in
breeding females (Heston, 1963). Hepatomas have
eosinophilic cytoplasmic inclusion bodies (Liebelt
et al., 1971., 1971). Good model of genetic predisposition to hepatocellular
tumours, susceptibility being associated with six chromosomal regions
(Dragani et al, 1995). Point mutations in H-ras do not generally play
a major or initiating role in spontaneous hepatocarcinogenesis in this
strain (Enomoto et al, 1993).
Lung adenomas 2-10% in fostered A substrain, leukaemia 6-30% (Muhlbock and Tengbergen, 1971). Occasional Harderian gland
tumours (Heston, 1963). Rare "lipomatous" hamartomas
or choristomas have been noted (Adkison et
Life-span in SPF fostered conditions intermediate in both sexes (11/17
= 590 days in males, 12/17 = 676 days in females). Liver tumours 9-23%,
lung tumours 2-10% and mammary tumours 21-36%. Heart defects 13-26% and
cystic ovaries 13-26% (Festing and Blackmore,
1971). Tail lesions similar in appearance to bit wounds were found
in grouped C3H/HeJ by Les (1972). Develop dystrophic
cardiac calcification which may be related to disturbed myocyte calcium
metabolism (Brunnert, 1997).
Can be made obese by a suitable diet (Fenton
and Dowling, 1953). Resistant to the development of aortic cartilaginous
metaplasia (contrast C57BL/6) (Qiao et al, 1995).
Resistant to diet-induced aortic fatty streak lesions which correlates
with a high level of paroxinase mRNA (contrast C57BL/6) (Shih et al, 1996).
Primary lung tumours 8% in males, 4% in breeding females and 10% in Virgin
females. Lymphatic leukaemia zero. Mammary adenocarcinomas zero in males,
12% in breeding females, 2% in virgin females (Hoag,
). Ovarian tumours 47% in Virgin and 37% in breeding females,
29% in force-bred females (Heston, 1963
91% in breeding males, 58% in Virgin and 30% in breeding females (Murphy,
). Life-span above average in both sexes (16/22 = 652 days in
males, 17/22 = 657 days in females). High gross tumour incidence in males
(5/22) (Storer, 1966
Normal physiology and biochemistry
Low blood pressure (15/17) (Mullink et al., 1975). Low serum calcium
in Fg substrain (5/6) but He substrain has high level at 4 months (1/6)
(Barrett et al., 1975., 1975). High serum
cholesterol (1/5) (Bruell et al., 1962.,
1962). High plasma cholesterol (11/11) and triglycerides (10/11). High
erythrocyte catalase (5/18) (Hoffman and
Rechcigl, 1971). Low serum haptoglobin level (10/11) (Peacock et al, 1967 , 1967). Low peripheral nerve conduction
velocity (6/6) (Hegmann, 1972). Low percentage
of time spent sleeping (5/6) with low percentage of slow-wave sleep (5/6)
and small diurnal variation (5/6) (Valatx
and Bugat, 1974). High brain glutamic acid decarboxylase (GABA) in
He-mg substrain (2/10) (Gaitonde
and Festing, 1976). High brain aromatic L-amino acid decarboxylase
(1/5) in C3H/2 substrain (Pryor et al., 1966.,
1966). Low metabolic rate (5/6) (Pennycuik, 1967).
High liver tyrosine aminotransferase level in fasted mice (1/10) (Blake,
1970). Low adrenal corticosteroid production (4/4) (Nandi et al., 1967., 1967). High peptidyl proline hydroxylase
activity in tumour tissue and mammary gland fat pad (1/5) (Cutroneo et al., 1973., 1973). Slow cell turnover as judged
by rate of clearance of DNA- bound radioactivity (14/17) (Heiniger et al., 1972., 1972). Harderian gland has a high
porphyrin content (2/16) (Margolis, 1971).
Low hepatic ammonia-lyase activity (5/6 and 6/6 in two substrains) (Hanford et al., 1974., 1974). Low spermatozoal
beta-glucuronidase activity (9/9) (Erickson, 1976).
Low basal level of renal glutathione S-transferase (4/4) but high basal
level of renal glutathione reductase (1/4) (Misra
et al 1991). Low hepatic nicotinamide N-methyltransferase levels (10/10)
(Scheller et al, 1996). Maintain normal
auditory sensitivity beyond one year of age in both HeJ and HeSnJ substrains,
but by 30 months there was little hearing function due to sensorineural
degeneration (Trune et al, 1996).
High level of alpha-fetoprotein in plasma at 7 days (2/6) (Adinolfi et al 1990). Resistant to the development of atherosclerosis
on a semi-synthetic high fat diet (cf 5/9) (Nishina
et al, 1993). Loci on chromosomes 1, 3, 5 and 11 are associated with
variation in high density lipoprotein levels with coordinate expression
of cholesterol-7-alpha hydroxylase in a cross involving atherosclerosis
susceptible C57BL/6 mice (Machleder et
Hepatic iodothyonine deiodinase activity was only 18% of that found in
C57BL/6 mice (Schoenmakers et al, 1993).
Decreased levels of deiodinase mRNA and hyperthyroxinemia associated with
a 21-base pair insert in the promoter region of the type 1 deiodinase
gene (Maia et al, 1995). Resistant to severe
hypercapnia with hypoxia assessed by elevated minute ventilation rate
(8/8) (Tankersley et al, 1994). Has
a slow and deep breathing pattern phenotype (contrast C57BL/6) (Tankersley et al, 1997). High intra-ocular pressure (1/4)
(John et al, 1997).
Low systolic blood pressure (19/19) (Schlager
and Weibust, 1967
). Low plasma cholinesterase activity in females
(18/22) (Angel et al, 1967
). High N'
methylnicotinamide oxidase activity (1/7) (Huff
and Chaykin, 1967
Low total leukocyte count (18/18), low erythrocyte count (16/18), low haematocrit
(18/18), low haemoglobin (17/18) (Russell
et al., 1951
., 1951). Small thymus/body weight ratio (5/6) (Belyaev et al., 1970
., 1970), small thymus/body weight
ratio (6/8 to 8/8, depending on age) (Albert
et al., 1965
., 1965). Large pituitary (1/6) (Sinha
et al., 1975
., 1975). Adrenal gland X zone large (1/8), with high
incidence of vacuolisation (2/6) (Delost and
). Low percentage of mice have accessory spleens
(9/9) (Hummel et al., 1966
., 1966). Many
Peyer's patches (2/7) (Hummel et al., 1966
1966). Plasma volume low (4/4) at 5.97 ml/100 g and red cell volume low
(4/4) at 4.64ml/100g body weight in He substrain (Kano and Mizuma, 197.4).
Intermediate proportion of sperm-head abnormalities (2/5, 13%) in C3H/HeJ
(Styrna et al 1991
). High retinal ganglion
cell number (24/24) in HeJ (Williams et
). High bone density of femur (1/11) (Beamer et al, 1996
Megakaryocytes have a higher average ploidy than all other mouse strains
tested. This is due to multiple additive alleles (McDonald and Jackson,
Large brain weight (15/18 male, 17/18 female) (Storer,
). Small brain/body weight ratio (19/20) (Roderick et al., 1973
Susceptible to skin ulceration to DMBA (cf. 13/22) (Thomas et al., 1973
., 1973). Sensitive to the development
of uterine tumours following treatment with DMBA at 4-weeks of age (cf
3/6) (Tsubura et al, 1993
to induction of subcutaneous tumours by 3-methylcholanthrene (1/14 to
4/14, depending on substrain) (Kouri et al.,
., 1973). Susceptible to tumour induction by 3-methylcholanthrene
in fostered and unfostered substrains (1/8 to 2/8) (Whitmire and Salerno, 1972
), (2/12) (Whitmire et al., 1971
., 1971). Susceptible to induction
of liver (1/6) but resistant to pulmonary (5/6) tumours by neonatally
administered DMBA (Flaks, 1968
). High susceptibility
to tumour induction by 3,4-benzpyrene (1/6) (Liebelt
et al., 1970
., 1970). High susceptibility to induction of mammary
tumours by urethane (2/7) (Bentvelzen
et al., 1970
., 1970). High incidence of gastric tumours after administration
of methylcholanthrene by gavage (2/5) (Akamatsu and Barton, 1974). Susceptible
to fibrosarcoma induction by methylcholanthrene (2/15 male, 1/15 female)
). Highly susceptible to the induction
of hepatocellular tumours by various carcinogens, with the volume of hepatic
lesions being >100-fold greater than in more resistant strains. Susceptibility
is linked to at least six chromosomal regions (Dragani et al, 1995). C3HxMSM
F1 hybrids treated with N-methyl-N-nitrosourea (MNU) develop squamous
cell carcinomas of the forestomach with about 20% and 15% having mutations
and p53, respectively (Masui
et al, 1997
Phenobarbitone in the diet to give an intake of 85mg/kg per day resulted
in 70% of animals developing basophilic nodules by 91 weeks of age (contrast
4% in C57BL/6), but no increase in liver carcinomas (Evans et al, 1992). However, there was a two-fold greater
level of DNA synthesis in C3H mice relative to C57BL/6 mice after partial
hepatactomy, though partial hepatectomy is a tumour promoter in C57BL/6
but not in C3H mice (Bennett et al, 1995).
Insensitive to histamine (9/9) (Brown, 1965).
Airways of C3H/HeJ hyporeactive to acetylcholine (c.f. 3/7) (Zhang et al, 1995). Resistant to teratogenic effect of
acetazolamide (5/6) (Green et al., 1973.,
1973). Pentobarbital i.p. induces hepatic epoxide hydrase (cf. 4/7) (Oesch et al., 1973., 1973). Sensitive to X-irradiation
(25/27) (Roderick, 1963). Long survival on
Warfarin (12/12) (Lush and Arnold, 1975).
Sensitive to hyperbaric oxygen (2/18) (Hill
et al., 1968., 1968). Sensitive uterine response to oestrogens (5/5)
(Chai and Dickie, 1966). Short hexobarbital
sleeping time (3/9) (Vesell, 1968). Long survival
in 90% oxygen (1/10) and highly susceptible to pulmonary hyaline-membrane
formation (1/10) (Lieberman and Kellog,
1967). Resistant to the induction of pulmonary fibrosis by bleomycin
(contrast C57BL/6) (Haston et al, 1996),
and irradiation though the sensitivity of lung fibroblasts to irradiation
in-vitro does not correlate with in-vivo sensitivity
(Dileto and Travis, 1996). Sensitive to
chloroform toxicity (cf. 4/9) (Deringer
et al., 1953., 1953). Susceptible to toxic effects of isoniazid (10/10)
(Taylor, 1976b). High ED50 to behavioural effects of nicotine (17/19)
(Marks et al 1989). Low self-selection
of nicotine (5/6) which is inversely correlated with sensitivity to nicotine-induced
seizures (Robinson et al, 1996).
Low bronchial reactivity (5/6) to methacholine and serotonin (Konno et al 1993). No increase in renal lipid peroxidation
following treatment with nickel (4/4) (Misra
et al 1991). Susceptible to biliary tract injury following oral dosing
with 500 micrograms of the fungal toxin sporidesmin (2/4) (Bhathal et al 1990). Low histamine release from peritoneal
mast cells induced by compound 48/80, a calcium dependent histamine releaser
( c.f. 5/8) (Toda et al 1989). High histamine
release from peritoneal mast cells induced by Ca2+ ionophore A23187 (
c.f. 7/8, contrast C57BL/6) (Toda et al 1989).
Cadmium highly hepatotoxic (1/5) (Shaikh et
al, 1993). Resistant (cf 3/8) to ozone-induced decreases of tracheal
potential (Takahashi et al, 1995, Kleeberger et al, 1993). Susceptible
to weight loss induced by cocaine, but this is attenuated by anisomycin
(cf SJL, CBA) (Shimosato et al, 1994).
Estrogen does not induce an increase in VLDL and LDL-cholesterol (like
BALB/c, contrast C57BL/6 and C57L)) (Srivastava,
Susceptible to skin ulceration by DMBA (cf. 13/22) (Thomas et al., 1973
., 1973). Sensitive to X-irradiation (23/27)
). Good ovulatory response
(94%) to 3 I.U. PMS (1/6), but poor response (33%) to 7 I.U. PMS. Response
facilitated by exposure to males (Zarrow et
., 1971). Susceptible (cf 5/8) to ozone-induced decreases
of tracheal potential (Takahashi et al,
Sensitive to amyloid induction (2/10) but low level of spontaneous amyloid
formation (Ram et al., 1969
., 1969). Low
lymphocyte phytohaemagglutinin response (38/43) (Heiniger et al., 1975
., 1975). Good immune response to small
doses of bovine gamma globulin (cf. 4/8) (Levine
and Vaz, 1970
). Poor immune response to Cholera A and B antigens (8/8)
(Cerny et al., 1971
., 1971). Good splenic
PFC immune response to pneumococcal polysaccharide (2/9) (Amsbaugh et al., 1972
., 1972). Females fail to reject male
skin grafts after 100 days (contrast nine strains) (Gasser and Silvers, 1971
). Poor immune response to ovomucoid
and ovalbumin (cf. 2/12) (Vaz et al., 1971
1971). Poor primary immune response to bovine serum albumin (5/6) (James and Milne, 1972
). Good immune response
to Salmonella anatum
(1/5) and S. senftenberg
lipopolysaccharide (Di Pauli, 1972
). Responder to
synthetic polypeptide Glu57
(cf. 3/7) (Pinchuk and Maurer, 1965). Good immune response to Vi antigen
(2/5) (Gaines et al., 1965
., 1965). Precipitating
and skin-sensitising antibodies have slow electrophoretic mobility (2/6)
). High antibody affinity to HSA
(3/9) (Petty et al., 1972
., 1972). Erythrocytes
have high agglutinability (cf. 14/25) (Rubinstein
et al., 1974
., 1974). Low immune response to ferritin in He substrain
(15/16) (Young et al., 1976
., 1976). Non-
discriminator between `H' and `L' sheep erythrocytes (cf. 6/18) (McCarthy and Dutton, 1975
). High anti-DNP antibody concentration
(2/7) (Paul et al., 1970
., 1970). Antibodies
to lipoid A antigen do not cross-react with sheep red blood cells (contrast
eight strains). Strain also resistant to toxic effect of Salmonella
lipopolysaccharide (1/8) (Rank et al.,
., 1969). Refractory to sensitising effects of HSF from Bordetella
to histamine (contrast sixteen strains) (Bergman and Munoz, 1968
Low level of "leakiness" when the scid mutation is maintained
on this genetic background (contrast CB17) (Nonoyama
et al, 1993).
Good immune response to Pro-Gly-Pro-ovalbumin (1/7) and (Pro-Gly- Pro)n
(2/7) (Fuchs et al., 1974., 1974). High
susceptibility (3/12) to IgE-mediated passive cutaneous anaphylaxis (De Souza et al., 1974., 1974). Good immune response
to Salmonella strasbourg lipopolysaccharide (1/7) (Di
Pauli, 1972). Low PHA- stimulated lymphocyte blastogenic response
in Ent substrain (6/6) (Hellman and Fowler,
1972). Erythrocytes of C3HeB/FeJ have a high agglutinability (cf.
14/25) (Rubinstein et al., 1974.,
1974). He substrain resistant to induction of anaphylactic shock by ovalbumin
(cf. 6/13) (Tanioka and Esaki, 1971).
He and HeN substrains are susceptible (2/12) to experimental autoimmune
orchitis induced by two or three sc injections with viable syngeneic testicular
germ cells without any adjuvants, but C3H/BiKi is resistant (12/12) (Tokunaga et al 1993). High immune response
to ganglio-series gangliosides in C3H/HeN (c.f. 2/10), but low response
in C3H/HeJ (c.f. 4/10) (Kawashima et al
1992). Anti-BPO IgE monoclonal antibody did not produce potent systemic
sensitization sufficient for provocation of lethal shock in most aged
(6 to 10 months) mice (c.f. 5/8) (Harada et
al 1991). Carries a strain-specific allele at the alpha globin locus
(Sato et al, 1996).
High natural killer cell response to the immunostimulent 7-allyl-8-oxoguanosine
(1/6) (Pope et al, 1994).
Resistant to infection by Salmonella typhimurium
strain C5 (5/7)
(Plant and Glynn, 1974
), Susceptible to
et al., 1972
., 1972). Experimental Mycoplasma pulmonis
results in acute pneumonia with severe hemorrhage, edema and often death
(Faulkner et al, 1995
to mammary tumour virus, which is carried in an active form in unfostered
substrains (Murray and Little, 1967
Susceptible to oncogenic effect of polyoma virus given at birth (Law,
). Susceptible to measles virus induced encephalitis, which correlates
with a high cytotoxic T-lymphocyte response (like C57BL/6, contrast BALB/c)
(Niewiesk et al, 1993
Susceptible to Mycobacterium marinum (2/9)(Shepard and Habas, 1967). Susceptible to infection by Mycobacterium
marinum (1/6) (Yamamoto et al 1991).
Susceptible to infection by Entamoeba histolytica (1/4) (Neal and Harris, 1975). Resistant to mouse
hepatitis virus (Bang and Warwick, 1960).
100% transmission of murine leukaemia virus (Scripps) through three successive
generations (cf. 2/5) (Jenson et al., 1976.,
1976). Highly susceptible to measles virus (cf. 3/6) (Rager-Zisman et al., 1976., 1976). The BiDa substrain is
susceptible (9/9) to tumorigenesis following infection with polyoma virus
in contrast with C57BL/6 (Freund et al 1992) and C57BR/cd due to a single
dominant gene Pyvs for susceptibility,
which may be identical to Mtv-7 (Lukacher
et al, 1995). Highly susceptible to tumour induction by polyoma virus
(1/9) (Freund et al, 1992). Following administration of murine cytomegalovirus,
C3H mice exhibited minimal carditis after neonatal or adult infection.
However neonatal infection appears to accelerate age-related cardiopathy,
which is severe in retired breeders of this strain. (contrast BALB/c and
C57BL/10) (Price et al 1991). Highly susceptible
to Lyme borreliosis (Borrelia burgdorferi) when inoculated at
3 weeks of age (1/5) and as adults. Mice inoculated at age 3 weeks also
developed polyarthritis, but severity was reduced when inoculated as adults.
Carditis was also common (Barthold et al
1990), and mice were susceptible to the development of arthritis (contrast
BALB/c) (Matyniak and Reiner, 1995).
Resistant to intra-vaginally innoculated Neisseria gonorrhoeae
(c.f. 5/5) (Johnson et al 1989). Resistant
(3/10) to infection with Ehrlichia risticii (Williams and Timoney, 1994). Susceptibile to infection
by Helicobacter felis with moderate to severe chronic active
gastritis in the body of the stomach, which increased over time (cf 4/6)
(Sakagami et al, 1996).
Substrain (which carries the lps
mutation) resistant to LCM virus
(76% survival) prior to 1970, but has now become susceptible (3% survival)
(Oldstone and Dixon, 1973
to LCM virus infection (1/5) (Oldstone and
). Resistant to induction of diabetes mellitus by encephalomyocarditis
virus (cf. 7/14) (Boucher et al., 1975
1975). Susceptible to lethal infection with Rickettsia akari
Kaplan, in contrast with seven other substrains of C3H and 24 other strains
(Anderson and Osterman 1980a
mammary tumor proviral loci have been identified by Lee and Eicher (1990
). High immunological response to Salmonella
porins (1/4) (Gonzales et al, 1995). Resistant to infection
with Mycobacterium paratuberculosis
(contrast BALB/c) (Tanaka et al, 1994
Susceptible, with high amylase response to the fungus Paracoccidioides
brasiliensis (cf 6/12) (Xidieh et al,
1994). Resistant to Leishmania major (contrast BALB/c) (Laskay et al, 1995,
Scott et al, 1996). Lipopolysaccharide mutant (lps) and non-mutant
mice are equally susceptible to Escherichia coli (Hopkins et al, 1996).
Highly susceptible to mammary tumour virus, but believed to be free of
the virus (Murray and Little, 1967
susceptibility to BALB/Tennant leukaemia virus (11/12) (Tennant,
). Resistant to induction of diabetes mellitus by encephalomyocarditis
virus (cf. 7/14) (Boucher et al., 1975
Breeding performance intermediate/good (5/25 He substrain, 10/25 He-mg
sub-line). Colony output 1.1 to 1.4 young/female/week. Litter size at
weaning 5.9 (8/25) (Festing, 1976a). Good reproductive performance (2/8),
litter size 6.4, sterility 10% (Nagasawa
et al., 1973
., 1973). Large litter size (1/6 to 3/6), high proportion
of females produce four or more litters (1/6) and high proportion of fertile
matings (1/6) (Fernandes et al., 1973
1973). Good breeding performance, 2.0 to 2.2 young per female per month
(9/24 to 7/24) in fostered and unfostered substrains, respectively (Hansen et al., 1973
., 1973). C3H/HeJ has
shorter and less regular oestrus cycles than C57BL/6J (Nelson et al 1992
). Early opening of vagina and first cornification
(1/3 compared with C57BL/6 and DBA/2), but late onset of cyclicity (3/3)
(Nelson et al 1990
High reproductive performance (1/8). Litter size 6.4 + 0.2, sterility 4%
(Nagasawa et al., 1973
Recommended host for the following transplantable tumours: lymphosarcoma
6C3HED and mammary adenocarcinomas C3HBA and H2712 (Kaliss, 1972). Recommended
host for sarcoma BP8 used as a model for screening potential anticancer
drugs (E.O.R.T.C. Screening Group, 1972). High mortality after neonatal
thymectomy (6/6) (Law, 1966a
High rate of spontaneous mutations (1/21) and total deviants (4/21) (Schlager and Dickie, 1967).
Recommended host for transplantable hepatoma H4 (Kaliss, 1972). High incidence
of spontaneous `deviants' (5/21) (Schlager
and Dickie, 1967
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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,