About 40-60% of mice of both sexes have ectopic cell clusters in layer I of the neocortex. Affected mice had better Morris maze learning and better long-term retention than the non-ectopic counterparts (Boehm et al, 1996a). They also had better reference memory, but less effective working memory than their non-ectopic counterparts in a Lashley III maze (Boehm et al, 1996b). Ectopic mice also took longer to learn a "working memory" water maze (Waters et al, 1997).
Embryonic stem cell lines have been established (Kawase et al, 1994). Like other H2b mice this strain does not express the class II H2 antigen, I-E. Mice bearing this antigen as a transgene do not develop the autoimmune syndrome (Merino et al, 1993).
Maint. by J, Ola.
Boehm G. W., Sherman G. F., Hoplight II B. J., Hyde L. A., Waters N. S., Bradway D. M., Galaburda A. M., and Denenberg V. H. (1996a) Learning and memory in the autoimmune BXSB mouse: Effects of neocortical ectopias and environmental enrichment. Brain Res. 726, 11-22. \par
Boehm G. W., Sherman G. F., Rosen G. D., Galaburda A. M., and Denenberg V. H. (1996b) Neocortical ectopias in BXSB mice: Effects upon reference and working memory systems. Cerebral Cortex 6, 696-700. \par
Kawase E., Suemori H., Takahashi N., Okazaki K., Hashimoto K., and Nakatsuji N. (1994) Strain difference in establishment of mouse embryonic stem (ES) cell lines. International Journal of Developmental Biology 38, 385-390. \par
Merino R., Iwamoto M., Fossati L., Muniesa P., Araki K., Takahashi S., Huarte J., Yamamura K. I., Vassalli J. D., and Izui S. (1993) Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain. Journal Of Experimental Medicine 178, 1189-1197. \par
Nabarra B., Dardenne M., and Bach J. F. (1990) Thymic reticulum of autoimmune mice. II: Ultrastructural studies of mice with lupus-like syndrome (NZB, BXSB, MRL/l). Journal of Autoimmunity 3, 25-36. \par
Theofilopoulos A. N., McConahey P. J., Izui S., Eisenberg R. A., Pereira A. B., and Creighton W. D. (1980) A comparitive immunologic analysis of several murine stains with autoimmune manifestations. Clin. Immunol. Immunopathol. 15, 258-278. \par
Waters N. S., Sherman G. F., Galaburda A. M., and Denenberg V. H. (1997) Effects of cortical ectopias on spatial delayed-matching-to-sample performance in BXSB mice. Behavioural Brain Research 84, 23-29. \par
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