Inbred Strains
of Mice: BXH
Inbr 30+. Set of 13 recombinant inbred strains developed by B.A.Taylor
from C57BL/6J x C3H/HeJ. Maint. by Ty. Strain BXH2 develop myeloid leukemia
as a result of the expression of an ecotropic murine leukaemia virus that
acts as an insertional mutagen altering the expression of cellular proto-oncogenes.
This is not passed through the germ line, but is passed from one generation
to the next by horizontal transmission (
Bedigian
et al, 1993). A homeobox locus
Meis1 is the site of viral
integration in 15% of tumours (
Moskow et al,
1995).
Bedigian
H. G., Shepel L. A., and Hoppe P. C. (1993) Transplacental transmission
of a leukemogenic murine leukemia virus. Journal of Virology
67, 6105-6109.
Moskow
J. J., Bullrich F., Huebner K., Daar I. O., and Buchberg A. M. (1995)
Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2
mice. Molecular and Cellular Biology 15, 5434-5443.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK