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Inbred Strains of Mice: BXH


Inbr 30+. Set of 13 recombinant inbred strains developed by B.A.Taylor from C57BL/6J x C3H/HeJ. Maint. by Ty. Strain BXH2 develop myeloid leukemia as a result of the expression of an ecotropic murine leukaemia virus that acts as an insertional mutagen altering the expression of cellular proto-oncogenes. This is not passed through the germ line, but is passed from one generation to the next by horizontal transmission (Bedigian et al, 1993). A homeobox locus Meis1 is the site of viral integration in 15% of tumours (Moskow et al, 1995).

Bedigian H. G., Shepel L. A., and Hoppe P. C. (1993) Transplacental transmission of a leukemogenic murine leukemia virus. Journal of Virology 67, 6105-6109. \par

Moskow J. J., Bullrich F., Huebner K., Daar I. O., and Buchberg A. M. (1995) Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Molecular and Cellular Biology 15, 5434-5443. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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