Inbred Strains
of Mice: BPL
Inbr (J, 1998) F55. White bellied agouti. Origin: Gunther Schlager, U.
of Kansas. Genetic selection for low blood pressure initiated in 1966
from a base population derived from an 8-way cross among LP/J, SJL/J,
BALB/cJ, C57BL/J, 129/J, CBA/J, RF/J and BDP/J. Inbreeding avoided until
F23 when several inbred substrains were initiated. Strain has low systolic
blood pressure, long life span (approx. 50% longer than BPH/2) and high
norephinephrine content in whole brain (
Schlager
1994) (see also BPH). Maintained by J.
Schlager G. (1994)
Genetic hypertension in the mouse, in Handbook of Hypertension Vol.
16 Experimental and Genetic Models of Hypertension (Ganten D. and
de Jong W., eds), pp. 158-172. Elsevier, Amsterdam, New York, Oxford.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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