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Inbred Strains of Mice: BL


Inbr: F108. Albino. Genet: a, b, c strain developed by Lynch from Bagg albino stock via Strong, and maintained at Rockefeller Institute since 1921.


Low mammary tumours, some lung tumours in older mice (Staats, 1976). Ovaries often appear pale and enlarged and have an infiltration of amyloid. Thought to be due to necrotising arteritis in which there is a thickening of the walls of the vessels to duodenum and ovaries due to a deposition of eosinophilic material within the intima and media (Deringer, 1959b). Aseptic necrosis of bone in 22% of females often resulting in fracture of femoral neck and other complications, so that the animals are severely crippled (Sokoloff and Haberman, 1958).

Deringer M. K. (1959b) Occurrence of tumors, particularly mammary tumors in agent-free strain C3HeB mice. J. Natl. Cancer Inst. 22, 995-1002.

Sokoloff L. and Haberman R. T. (1958) Idiopathic necrosis of bone in small animals. Arch. Pathol. 65, 323-330.

Staats J. (1976) Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36, 4333-4377.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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