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Inbred Strains of Mice: BDP

BDP

Inbr: F94. Pink-eyed fawn. Genet: a, b, d, p, rd, se. Developed by W. H. Gates 1926 from a dilute brown female from Little and a pink-eyed female from Strong (Staats, 1976). Inbred since 1926. Maint. by J.


Behaviour

Low food drive (14/15) and high emotionality (2/15) (Thompson, 1953). Nervous (Staats, 1976).


Life-span and spontaneous disease

Short life-span in conventional conditions (4/22 = 421 days in males, 6/22 = 468 days in females) (Storer, 1966). Frequent mammary tumours, polycystic or granular kidneys (Staats, 1976).


Normal physiology and biochemistry

High plasma cholesterol at 12 and 24 weeks (3/8) (Weibust, 1973). Low porphyrin content of Harderian gland (2/16) (Margolis, 1971). High susceptibility to audiogenic and electroconvulsive seizures (2/6) (Deckard et al., 1976., 1976). High serum complement activity (c.f. 8/26) (Ong et al 1989)


Anatomy

Large kidney/body weight ratio (3/21) (Schlager, 1968).


Drugs

Resistant to X-irradiation (8/27) (Roderick, 1963).


Immunology

Erythrocytes have a high agglutinability (cf. 14/25) (Rubinstein et al., 1974., 1974).


Infection

Murine acquired immune deficiency (MAIDS) is an immunosuppressive disease of mice induced by infection with the LP-BM5 murine leukemia retrovirus. Strain BDP has a novel disease phenotype with recovery of immune function after a period of profound immune suppression. This is inherited as a dominant character in crosses with both susceptible and resistant strains (Gilmore, 1997).


Deckard B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental patterns of seizure susceptibility in inbred strains of mice. Devel. Psychobiol. 9, 17. \par

Gilmore G. L. (1997) Recovery from retrovirus-induced immune suppression in BDP/J mice: Dominance of the 'regressor' phenotype. Immunol. 90, 7-13. \par

Margolis F. L. (1971) Regulation of porphyrin biosynthesis in the Harderian gland of inbred mouse strains. Arch. Biochem. Biophys. 145, 373-381. \par

Ong G. L. and Mattes M. J. (1989) Mouse strains with typical mammalian levels of complement activity. J. Immunol. Methods 125, 147-158. \par

Roderick T. H. (1963) The response of twenty-seven inbred strains of mice to daily doses of whole-body X-irradiation. Radiation Res. 20, 631-639. \par

Rubinstein P., Liu N., Strenn E. W., and Decary F. (1974) Electrophoretic mobility and agglutinability of red blood cells: a `new' polymorphism in mice. J. Exp. Med. 139, 313-322. \par

Schlager G. (1968) Kidney weight in mice: strain differences and genetic determination. J. Hered. 59, 171-174. \par

Staats J. (1976) Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36, 4333-4377. \par

Storer J. B. (1966) Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21, 404-409. \par

Thompson W. R. (1953) The inheritance of behaviour: behavioural differences in fifteen mouse strains. Can. J. Psychol. 7, 145-155. \par

Weibust R. S. (1973) Inheritance of plasma cholesterol levels in mice. Genetics 73, 303-312. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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