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Inbred Strains of Mice: AU


Inbr: F? + 35. Genet: a, U, rd+. Origin: R. A. Fisher, about 1937. 50% Gruneberg's CBA, 28.5% Fisher's colour stocks and 21.5% Gruneberg's wavy stock, the latter two being unrelated stocks of American origin. To Medawar 1947, to Silvers at F23 in 1957, to Jackson Laboratory 1967.


: Females do not reject male isografts. Unusual induction of kidney beta-glucuronidase by testosterone (Staats, 1976). High plasma cholinesterase activity (1/22) (Angel et al., 1967., 1967). Resistant to skin ulceration by DMBA (cf. 9/22) (Thomas et al., 1973., 1973). High degree of genetic distinctiveness (2/27) (Taylor, 1972). Carries no detectable endogenous ecotropic MuLV DNA sequences (Jenkins et al 1982). F1 hybrid crosses with CBA have been suggested as a good model for auditory research (Henry and McGinn 1992). Resistant to the induction of arthritis by type II collagen (Ortman et al, 1994).

Angel C. R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability of plasma cholinesterase activity in inbred mouse strains. Science 156, 529-530.

Henry K. R. and McGinn M. D. (1992) The mouse as a model for human audition. A review of the literature. Audiology 31, 181-189.

Jenkins N. A., Copeland N. G., Taylor B. A., and Lee B. K. (1982) Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol. 43, 26-36.

Ortman R. A., Holderbaum D., Qu X. M., Banerjee S., and Haqqi T. M. (1994) BUB/BnJ (H-2(q)) is a TCR deletion mutant mouse strain (TCR Vbetaa, KJ16- ) that is susceptible to type II collagen-induced arthritis. J. Immunol. 152, 4175-4182.

Staats J. (1976) Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36, 4333-4377.

Taylor B. A. (1972) Genetic relationship between inbred strains of mice. J. Hered. 63, 83-86.

Thomas P. E., Hutton J. J., and Taylor B. A. (1973) Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74, 655-659.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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