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Inbred Strains of Mice: APS


Inbr. (1998) F26. Albino, c. Origin: Outbred Swiss Webster mice from Connaught Laboratories, Toronto, Canada, selected by Casley and Whitehouse, Banting Research Centre, Ottawa, Canada, for elevated serum alanine aminotransferase (ALT) following administration of 150mg/kg acetaminophen per os, with brother x sister mating started in 1993 (see also APS).


Males and females show approx. 2-fold increase in caffein 3-demethylation relative to strain APN. CYP1A2 mRNA and enzyme activity are also elevated approx 2-fold relative to the APN strain (Casley et al, 1997a,b)

Casley W. L., Menzies J. A., Girard M., Larocque L., Mousseau N., Whitehouse L. W., and Moon T. W. (1997a) Differences in caffein 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains. Fundam. Appl. Toxicol. 40, 228-237. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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