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Phenotype Images associated with this Gene
Symbol
Name
ID 		Fbn1
fibrillin 1
MGI:95489


10 phenotype image(s) for Fbn1 alleles
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Click on allele symbol for full phenotype details.

Caption: Thick skin in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa mice (details)
Represented Alleles:
Fbn1tm3.2Lysa, fibrillin 1; targeted mutation 3.2, Lynn Y Sakai
Copyright: This image is from Sengle G, PLoS Genet 2012 Jan;8(1):e1002425, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:181493
Caption: Microfibril abnormalities in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa skin (details)
Represented Alleles:
Fbn1tm3.2Lysa, fibrillin 1; targeted mutation 3.2, Lynn Y Sakai
Copyright: This image is from Sengle G, PLoS Genet 2012 Jan;8(1):e1002425, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:181493
Caption: Fragmentation of aortic root elastic lamellae in Fbn1tm1.2Lysa/Fbn1+ mice (details)
Represented Alleles:
Fbn1tm1.2Lysa, fibrillin 1; targeted mutation 1.2, Lynn Y Sakai
Copyright: This image is from Charbonneau NL, J Biol Chem 2010 Aug 6;285(32):24943-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165897
Caption: Perturbed microfibril structure in Fbn1tm1.2Lysa/Fbn1tm1.2Lysa mice (details)
Represented Alleles:
Fbn1tm1.2Lysa, fibrillin 1; targeted mutation 1.2, Lynn Y Sakai
Copyright: This image is from Charbonneau NL, J Biol Chem 2010 Aug 6;285(32):24943-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165897
Caption: Fbn1tm3Rmz/Fbn1tm3Rmz mice exhibit aortic aneurysm and lesions, malformed ribs, and thinner intercostal muscles (details)
Represented Alleles:
Fbn1tm3Rmz, fibrillin 1; targeted mutation 3, Francesco Ramirez
Copyright: This image is from Carta L, J Biol Chem 2006 Mar 24;281(12):8016-23 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:110586
Caption: Fbn1tm3Rmz/Fbn1tm3Rmz Fbn2tm1Rmz/Fbn2tm1Rmz and Fbn1tm3Rmz/Fbn1+ Fbn2tm1Rmz/Fbn2tm1Rmz mice show poor organization of the aorta wall (details)
Represented Alleles:
Fbn1tm3Rmz, fibrillin 1; targeted mutation 3, Francesco Ramirez
Fbn2tm1Rmz, fibrillin 2; targeted mutation 1, Francesco Ramirez
Copyright: This image is from Carta L, J Biol Chem 2006 Mar 24;281(12):8016-23 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:110586
Caption: Clinical view of wild-type and Fbn1tm2Rmz/Fbn1tm2Rmz littermates (details)
Represented Alleles:
Fbn1tm2Rmz, fibrillin 1; targeted mutation 2, Francesco Ramirez
Copyright: This image is from Pereira L, Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3819-23. Copyright 1999 National Academy of Sciences, U.S.A. J:54081
Caption: Histopathology of Fbn1tm2Rmz/Fbn1tm2Rmz mice between 6 weeks and 3 months of age. (details)
Represented Alleles:
Fbn1tm2Rmz, fibrillin 1; targeted mutation 2, Francesco Ramirez
Copyright: This image is from Pereira L, Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3819-23. Copyright 1999 National Academy of Sciences, U.S.A. J:54081
Caption: Histopathology and immunohistochemistry of Fbn1tm2Rmz/Fbn1tm2Rmz mice between 3 and 6 months of age. (details)
Represented Alleles:
Fbn1tm2Rmz, fibrillin 1; targeted mutation 2, Francesco Ramirez
Copyright: This image is from Pereira L, Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3819-23. Copyright 1999 National Academy of Sciences, U.S.A. J:54081
Caption: Fbn1Tsk/Fbn1+ skin exhibits abnormal organization and distribution of microfibrillar arrays (details)
Represented Alleles:
Fbn1Tsk, fibrillin 1; tight skin
Copyright: This image is from Kielty CM, J Cell Biol 1998 Mar 9;140(5):1159-66, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:46405
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory