Phenotype Image Detail

Image

Caption

Skin phenotype. (b) Hematoxylin and eosin staining of skin from 10 month old wild-type (Fbn1^+/+), heterozygous Fbn1^tm3.2Lysa/Fbn1⁺ (Fbn1^WMdelta/+), and homozygous Fbn1^tm3.2Lysa/Fbn1^tm3.2Lysa (Fbn1^{WMdelta/WMdelta}) littermates. Dermal fibers in the mutant skin appeared to be thicker and more densely packed when compared to the wild-type littermate skin. Scale bar = 50 um. (c) Masson's trichrome staining of skin from the same 10 month old littermates as in (b). Heterozygous and homozygous mutant skin showed increased collagen deposition. In addition, in both (b) and (c), the dermis appeared to be wider with a strikingly diminished hypodermal fat layer. Scale bar = 50 um.

Copyright

This image is from Sengle G, PLoS Genet 2012 Jan;8(1):e1002425, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:181493

Associated Alleles

Symbol	Name
Fbn1^tm3.2Lysa	fibrillin 1; targeted mutation 3.2, Lynn Y Sakai

Associated Genotypes

Allelic Composition	Genetic Background
Fbn1^tm3.2Lysa/Fbn1^tm3.2Lysa	Not Specified
Fbn1^tm3.2Lysa/Fbn1^+	Not Specified