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Phenotype Images associated with this Gene
Symbol
Name
ID
App
amyloid beta (A4) precursor protein
MGI:88059


12 phenotype image(s) for App alleles
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Caption: Plaque-associated tau pathology in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 mice (details)
Represented Alleles:
Tg(Camk2a-tTA)1Mmay, transgene insertion 1, Mark Mayford
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz, transgene insertion 9191, Kathleen R Zahs
Copyright: This image is from Liu P, PLoS One 2015;10(5):e0126317, an open-access article distributed under the terms of the Creative Commons Attribution License. J:235351
Caption: Age-related amyloid beta plaque progression in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 mice (details)
Represented Alleles:
Tg(Camk2a-tTA)1Mmay, transgene insertion 1, Mark Mayford
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz, transgene insertion 9191, Kathleen R Zahs
Copyright: This image is from Liu P, PLoS One 2015;10(5):e0126317, an open-access article distributed under the terms of the Creative Commons Attribution License. J:235351
Caption: Plaque-associated neuroinflammation and abnormal neuronal architecture in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 mice (details)
Represented Alleles:
Tg(Camk2a-tTA)1Mmay, transgene insertion 1, Mark Mayford
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz, transgene insertion 9191, Kathleen R Zahs
Copyright: This image is from Liu P, PLoS One 2015;10(5):e0126317, an open-access article distributed under the terms of the Creative Commons Attribution License. J:235351
Caption: Neuroinflammation and abnormal neuronal architecture in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 mice (details)
Represented Alleles:
Tg(Camk2a-tTA)1Mmay, transgene insertion 1, Mark Mayford
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz, transgene insertion 9191, Kathleen R Zahs
Copyright: This image is from Liu P, PLoS One 2015;10(5):e0126317, an open-access article distributed under the terms of the Creative Commons Attribution License. J:235351
Caption: Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35Gt(RRK261)Byg/Vps35+ Tg(APPSWE)2576Kha/0 mice (details)
Represented Alleles:
Tg(APPSWE)2576Kha, transgene insertion 2576, Karen Hsiao Ashe
Vps35Gt(RRK261)Byg, VPS35 retromer complex component; gene trap RRK261, BayGenomics
Copyright: This image is from Wen L, J Cell Biol 2011 Nov 28;195(5):765-79, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:178937
Caption: Beta-amyloid plaques in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and neurofibrillary tangles in Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/0 mice (details)
Represented Alleles:
Mapttm1(EGFP)Klt, microtubule-associated protein tau; targeted mutation 1, Kerry Lee Tucker
Tg(APPswe,PSEN1dE9)85Dbo, transgene insertion 85, David R Borchelt
Tg(MAPT)8cPdav, transgene insertion 8c, Peter Davies
Copyright: This image is from Phillips M, PLoS One 2011;6(5):e19567, an open-access article distributed under the terms of the Creative Commons Attribution License. J:172426
Caption: Increase in creatine deposits in hippocampus of Tg(PRNP-APPSweInd)8Dwst/0 mice with age (details)
Represented Alleles:
Tg(PRNP-APPSweInd)8Dwst, transgene insertion 8, David Westaway
Copyright: This image is from Kuzyk A, J Biol Chem 2010 Oct 8;285(41):31202-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166801
Caption: Amyloid beta deposits in Tg(PRNP-APPSweInd)8Dwst/0 mouse brain (details)
Represented Alleles:
Tg(PRNP-APPSweInd)8Dwst, transgene insertion 8, David Westaway
Copyright: This image is from Kuzyk A, J Biol Chem 2010 Oct 8;285(41):31202-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166801
Caption: Amyloid beta deposits in Apptm3.1Zhe/Apptm3.1Zhe Psen1tm1Mpm/Psen1tm1Mpm mice (details)
Represented Alleles:
Apptm3.1Zhe, amyloid beta (A4) precursor protein; targeted mutation 3.1, Hui Zheng
Psen1tm1Mpm, presenilin 1; targeted mutation 1, Mark P Mattson
Copyright: This image is from Li H, J Biol Chem 2010 Oct 1;285(40):30598-605 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166379
Caption: Neuromuscular synapse defects in Apptm3.1Zhe/Apptm3.1Zhe Aplp2tm1Dbo/Aplp2tm1Dbo mice (details)
Represented Alleles:
Aplp2tm1Dbo, amyloid beta (A4) precursor-like protein 2; targeted mutation 1, David R Borchelt
Apptm3.1Zhe, amyloid beta (A4) precursor protein; targeted mutation 3.1, Hui Zheng
Copyright: This image is from Li H, J Biol Chem 2010 Oct 1;285(40):30598-605 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166379

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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory