About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b227Clo
Name: Mutant line 227; Bench to Bassinet Program (B2B/CVDC), mutation 227 Cecilia Lo
MGI ID: MGI:5437098
Synonyms: Scrappy
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 227-002-NC exhibits dextrocardia with duplicated inferior vena cava (IVC) and parallel outflow tracts which is diagnosed as DORV by EFIC imagingb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-002-NC exhibits dextrocardia with inverted liver lobationb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack of 227-007-NC in the coronal plane reveals dextrocardia, DORV, AVSD (subaortic) {A,L,L}
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-127-LB displays dextrocardia, dextrogastria and left sided liver indicative of heterotaxyb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-127-LB displays dextrocardia, dextrogastria and a small spleenb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack in the coronal plane of 227-127-LB reveals mirror image dextrocardia and mVSD
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-127-LB displays dextrogastria and midline liverb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Videomicroscopy of mutant 227-127-LB airway cilia reveals patches of immotile and dyskinetic cilia
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-002-NB displays mesocardia and cystic lungsb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack in the coronal plane of 227-002-NB reveals mesocardia, mVSD, dilated atria/ventricle, lung cysts, and dilated venous return
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-118-LA exhibits dextrocardia with RAA, hypoplastic morphological RV, and dual IVC which is confirmed by EFIC imagingb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack in the coronal plane of 227-118-LA reveals dextrocardia, hypoplastic mRV, mVSD, right atrial isomerism, and dual IVC
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-118-LA has malaligned sternal vertebrab2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack of 227-002-ND in coronal plane reveals ventricular septal hypertrophy
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
b2b227.2Clo/b2b227.2CloC57BL/6J-b2b227.2Clo
2D micro-MRI image stack of 227-085-LA in coronal plane reveals ventricular hypertrophy
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
b2b227.2Clo/b2b227.2CloC57BL/6J-b2b227.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory