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Phenotype Images associated with this Allele
Nomenclature
Symbol: 2410089E03Rikb2b012Clo
Name: RIKEN cDNA 2410089E03 gene; Bench to Bassinet Program (B2B/CVDC), mutation 012 Cecilia Lo
MGI ID: MGI:5297398
Synonyms: Heart Under Glass, Hug
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 012-029-NB has RAA, DORV, and pulmonary stenosis2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-NB has microgantnhia, micropthalmia and cleft lip2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-NB has a cleft lip and polydactyly2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-NB has polydactly on all four limbs2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC imaging of mutant 012-029-NB (E16.5) reveals DORV, right aortic arch, VSD, AVSD, and stenotic pulmonary artery (PA)2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-029-NB in the coronal view reveals DORV, subaortic VSD, hypoplastic PA, common AV valve, and right aortic arch
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-012-3 (E14.5) has DORV2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-012-3 (E14.5) in the sagittal view reveals DORV and right descending aorta
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-012-3 (E14.5) in the coronal view reveals DORV, PS, VSD, and ASD
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-003-2 (E16.5) has polydactly2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-003-2 (E16.5) has a cleft palate2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-003-2 (E16.5) presents with PTA2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-003-2 (E16.5) has hypoplastic lungs2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Ultrasound imaging of mutant 012-003-2 in the sagittal view reveals single outflow tract
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Ultrasound imaging of mutant 012-003-2 in the sagittal view reveals single outflow tract regurgitation
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2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Ultrasound imaging of mutant 012-003-2 in the transverse view reveals atrioventricular defects
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2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Ultrasound imaging of mutant 012-003-2 in sagittal view reveals polydactyly
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Ultrasound imaging of mutant 012-003-2 in the sagittal view reveals cleft palate
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-013-1 (E13.5) presents with polydactyly2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-013-1 (E13.5) reveals no formation of the sternum2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-013-1 (E13.5) presents with PTA2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-013-1 (E13.5) in the coronal plane shows VSD, ASD, PT, hypoplastic lung, and PTA
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-014-1 (E16.5) has a cleft lip2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-014-1 (E16.5) presents with polydactyly2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-014-1 (E16.5) has an abnormal sternum2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-014-1 (E16.5) reveals right aortic arch and DORV2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-014-1 (E16.5) has a duplex left kidney2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC imaging of mutant 012-014-1 reveals DORV, right aortic arch, thin ventricles, ASD and VSD2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-014-1 (E16.5) in the coronal plane shows thin ventricles, ASD, DORV, VSD, LV, RAA, and hypoplastic PT at DA
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-LA present with a cleft lip2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-LA presents with a cleft palate2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-LA has an incomplete fusion of the sternum and a malalignment of the ribs2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-LA has polydactyly2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-LA kidney is a duplex with a few small cysts2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Immunofluorescence of mutant 012-029-LA collecting duct2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Immunofluorescence of mutant 012-029-LA ureteric bud. Cilia in ureteric buds and collecting ducts are shorter than normal2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-033-2 (E15.5) has a cleft palate2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-033-2 (E15.5) in the coronal plane shows AVSD, common atria, and hypoplastic RV
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Immunofluorescence of mutant 012-033-2 (E15.5) ureteric bud with very short cilia2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-019-2 in the coronal plane shows AVSD, RAA, and stenotic PT
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-NC presents with cleft lip and micrognathia2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-NC has polydactyly2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-029-NC has RAA and pulmonary stenosis2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-029-NC in the coronal plane shows AVSD, common atrium, hypoplastic PA, right atrial isomerism, RAA, and stenotic PT
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-033-1 (E15.5) has severe edema with harelip and cleft palate2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012-033-1 (E15.5) has DORV and pulmonary stenosis2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of mutant 012-033-1 (E15.5) in the coronal plane shows AVSD, common atria, DORV, and PT stenosis
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012A-133-NB has polydactyly on all limbs, a short snout, and micrognathia2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012A-133-NB has a cleft lip2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012A-133-NB is diagnosed with DORV, hypoplastic PA, and biventricular hypertrophy2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of 012A-133-NB in the coronal view shows DORV, AVSD, hypoplastic PA, common PA which bifurcates into L and R branches, anomolous coronary vein and biventricular hypertrophy
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012A-133-NC has polydactly on all limbs, a short snout, and micrognathia2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012A-133-NC has a cleft palate2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Mutant 012 A-133-NC is diagnosed with DORV, hypoplastic PA, and biventriucalr hypertrophy2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
EFIC Summary2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo
Serial 2D EFIC image stack of 012A-133-NC in the coronal view exhibits DORV, AVSD, hypoplastic PA, common PA which bifurcates into L and R branches, anomolous coronary vein, biventricular hypertrophy and left atrial isomerism
Click thumbnail to play movie.
2410089E03Rikb2b012Clo/2410089E03Rikb2b012CloC57BL/6J-2410089E03Rikb2b012Clo

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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory