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Phenotype Image Detail
Image
Caption Representative microphotographs of hepatocytes from a control mouse injected with corn oil alone in the presence of doxycycline [Rblox/lox MYCOff (WT)] and a mouse injected with tamoxifen in the absence of doxycycline, Rb1tm3Tyj/Rb1tm3Tyj Tg(tetO-MYC)36aBop/0 Tg(Cebpb-tTA)5Bjd/0 (Rbdelta/delta MYCOn) are shown. Arrows show a small nucleus in the control mouse and a large nucleus in the mutant mouse indicating increased ploidy in hepatocytes.
Copyright This image is from Saddic LA, PLoS One 2011;6(5):e19758, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172430
Associated
Alleles
Symbol Name
Rb1tm3Tyj RB transcriptional corepressor 1; targeted mutation 3, Tyler Jacks
Tg(Cebpb-tTA)5Bjd transgene insertion 5, Hermann Bujard
Tg(tetO-MYC)36aBop transgene insertion 36a, J Michael Bishop
Associated
Genotypes
Allelic Composition Genetic Background
Rb1tm3Tyj/Rb1tm3Tyj
Tg(tetO-MYC)36aBop/0
Tg(Cebpb-tTA)5Bjd/0
involves: FVB/N * NMRI

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory