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Phenotype Image Detail
Image
Caption Altered dopamine neurons in the ventral midbrain of Ptentm1Hwu/Ptentm1Hwu Slc6a3tm1.1(cre)Bkmn/Slc6a3+ (KO) mice. Sections processed for tyrosine hydroxylase (TH) immunostaining show a significant increase in the number of TH immunopositive profiles in the substantia nigra compacta (SNc) and ventral tegmental area (VTA) of adult mutant animals when compared to controls (A and B). The total area covered by TH positive staining was significantly increased in mutant animals when compared to controls. Increase in the size of the mesolimbic and nigrostriatal projecting structures are due not only to an increase in the number of dopamine (DA) neurons, but also to an increase in neuronal size and in dendritic outgrowth (see inserts in A and B). Sections correspond to Bregma -3.16 mm with reference to Franklin and Paxinos (1997). Scale bar corresponding to high magnification, 250 um, and low magnification, 25 um.
Copyright This image is from Diaz-Ruiz O, PLoS One 2009;4(9):e7027, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:153622
Associated
Alleles
Symbol Name
Ptentm1Hwu phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Slc6a3tm1.1(cre)Bkmn solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1.1, Cristina M Backman
Associated
Genotypes
Allelic Composition Genetic Background
Ptentm1Hwu/Ptentm1Hwu
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129S4/SvJae * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory