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Phenotype Image Detail
Image
Caption Iron accumulates in specific brain regions of Ireb2tm1.1Eal/Ireb2tm1.1Eal (Irp2-/-) mice. Coronal sections from male mutant and wild-type brains from rostral (top) to caudal (bottom) were selected to show iron accumulation in specific regions of brain. Ferric iron was detected using DAB enhanced Perls' stain. Ctx cortex, CB cerebellum, CPu caudate putamen, cc corpus collosum, Gp globus pallidus, Hy hypothalamus, PAG, periaqueductal gray; SC superior colliculus, SN substantia nigra and Thl thalamus.
Copyright This image is from Zumbrennen-Bullough KB, PLoS One 2014;9(6):e98072, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:217335
Associated
Alleles
Symbol Name
Ireb2tm1.1Eal iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold
Associated
Genotypes
Allelic Composition Genetic Background
Ireb2tm1.1Eal/Ireb2tm1.1Eal B6J.129-Ireb2tm1.1Eal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory