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| Caption | Cilk1tm1a(KOMP)Mbp/Cilk1tm1a(KOMP)Mbp (Icktm1a/tm1a) mutant mice have endocrine-cerebro-osteodysplasia syndrome-like features. (B) E15.5 mutant embryos showed extensive edema at the head and back (red arrowhead). (Scale bars, 1.5 mm.) (C) Mutants exhibited cleft palates in the roof of the oral cavity (Left, asterisk). (Scale bars, 1 mm.) Coronal sections further demonstrate the cleft palate in mutant embryos (Right). (Scale bars, 300 um.) (D) Developing telencephalon in mutant embryos showed severely dilated ventricles. (Scale bars, 300 um.) (E) E15.5 mutant forelimbs displayed polydactyly (Upper). (Scale bars, 200 um.) Additionally, alcian blue/ alizarin red staining in E18.5 mutant embryos revealed delayed ossification in the digits and severely distorted and shortened long bones (Lower). (Scale bars, 500 um.) | ||||||
| Copyright | This image is from Moon H, Proc Natl Acad Sci U S A 2014 Jun 10;111(23):8541-6. Copyright 2014 National Academy of Sciences, U.S.A. J:211652 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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