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Phenotype Image Detail
Image
Caption Specific deletion of Lyn in dendritic cells (DCs) causes lupus-like autoimmune disease. (A) Kidney sections from 8-month-old control, Lyntm1Sor/Lyntm1Sor (lyn-/-), and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 (lynf/f Cd11c-cre+) mice were analyzed for signs of nephritis (H&E staining, Upper) and the presence of C3 deposit (Lower). Arrowheads and arrows indicate enlarged glomeruli and inflammatory foci, respectively. Representative pictures are shown; the presence and severities of the disease were graded. Scale bars, 100 um. (B) Sera from 6-month-old control and mutant mice were used for detection of IgG ANAs on fixed Hep-2 ANA slides. Representative pictures of six to eight mice per group are shown.
Copyright This image is from Lamagna C, Proc Natl Acad Sci U S A 2013 Aug 27;110(35):E3311-20. Copyright 2013 National Academy of Sciences, U.S.A. J:200745
Associated
Alleles
Symbol Name
Lyntm1.1Calo LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1.1 Clifford A Lowell
Lyntm1Sor LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Philippe Soriano
Tg(Itgax-cre)1-1Reiz transgene insertion 1-1, Boris Reizis
Associated
Genotypes
Allelic Composition Genetic Background
Lyntm1Sor/Lyntm1Sor involves: 129S4/SvJaeSor
Lyntm1.1Calo/Lyntm1.1Calo
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory