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Phenotype Image Detail
Image
Caption Posterior view of a wild-type mouse illustrates the normal location of the aorta and efferent vessels (A). Posterior view of Ts(1716)65Dn/0 mouse shows an aberrant right subclavian artery (RSA) arising from the distal part of the aortic arch and describing a retrooesophagian loop (B). Haematoxylin-eosin staining of histological crosssections illustrates full septation of the ventricles with individualized valves in wild-type (C) while mutant heart cross-section shows an upper communication of the ventricles (D; arrow). This cardiovascular anomaly was observed in 1 in 18 mutant dead newborns. LSA, left subclavian artery; RSA, right subclavian artery; DA, descending aorta; RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; Sept, septum; OT, outflow tract. Scale bars represent 1 mm in A, B and 400 um in C.
Copyright This image is from Raveau M, PLoS Genet 2012 May;8(5):e1002724, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185269
Associated
Alleles
Symbol Name
Ts(1716)65Dn trisomy, Chr 16 translocation to Chr 17, Davisson 65
Associated
Genotypes
Allelic Composition Genetic Background
Ts(1716)65Dn/0 involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory