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| Caption | Body weight of male control and Ghrtm1.1Dlr/Ghrtm1.1Dlr Tg(Ins2-cre)25Mgn/0 mice fed regular chow (RC) or high fat diet (HFD). (B) Intraperitoneal glucose tolerance (GTT) in male mice after 24 weeks on HFD. Mutant mice did not exhibit first-phase glucose-stimulated insulin secretion (GSIS) (C), but displayed normal first-phase arginine-stimulated (Arg-stimulated) insulin secretion (D). Numbers in parentheses indicate sample size. (E) HFD-induced islet hyperplasia is shown by immunostaining using anti-insulin antibody. Scale bars: 200 um. (F) Beta cell mass was quantified in insulin-stained pancreas sections. (G) GSIS in isolated islets from obese mice in response to different glucose (Glu) concentrations and in the presence of KCl or glibenclamide (Glib). (H) Arginine-simulated insulin secretion in isolated islets from obese mice. *P < 0.05. | ||||||
| Copyright | This image is from Wu Y, J Clin Invest 2011 Jun 1;121(6):2422-6 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173909 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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