Ghr^tm1.1Dlr
Targeted Allele Detail

Summary

• Symbol: Ghr^tm1.1Dlr
• Name: growth hormone receptor; targeted mutation 1.1, Derek LeRoith
• MGI ID: MGI:5056123
• Synonyms: Ghr-floxed, Ghr^L
• Gene: Ghr Location: Chr15:3347237-3612834 bp, - strand Genetic Position: Chr15, 1.84 cM
• Alliance: Ghr^tm1.1Dlr page

High fat diet-induced obesity causes impaired glucose tolerance and insulin secretion in Ghr^tm1.1Dlr/Ghr^tm1.1Dlr Tg(Ins2-cre)25Mgn/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173909
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP1 site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP2 site was inserted downstream of exon 4. Flpo-mediated recombination removed the neo cassette and left exon 4 floxed. (J:173909)

Generation of the conditional Ghr^tm1.1Dlr allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghr Mutation: 49 strains or lines available

References

• Original: J:173909 Wu Y, et al., Growth hormone receptor regulates beta cell hyperplasia and glucose-stimulated insulin secretion in obese mice. J Clin Invest. 2011 Jun 1;121(6):2422-6
• All: 6 reference(s)