About   Help   FAQ
Phenotype Image Detail
Image
Caption Rab25 deficiency promotes intestinal adenoma formation in ApcMin/Apc+ mice. (A) Gross appearance of small intestine from ApcMin/Apc+ (APCMin/+;Rab25+/+) and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (APCMin/+;Rab25-/-) mice. Rab25-deficient mice showed an increase in tumor numbers and size throughout the intestine. (B) Anatomical distribution of polyps in small intestine (SI) of ApcMin/Apc+ and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo mice. Polyp number was determined in the proximal, middle, and distal intestine as well as in the total intestines of ApcMin/Apc+ (+/+) (n = 7), ApcMin/Apc+ Rab25tm1Jrgo/Rab25+ (+/-) (n = 16), and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (-/-) (n = 12) mice. The distal intestine showed a greater increase in the number of polyps than the proximal intestine. ApcMin/Apc+ Rab25tm1Jrgo/Rab25+ mice also showed a significant increase in tumor numbers that was intermediate between ApcMin/Apc+ and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo mice. Data represent mean +/- SEM. (C) Representative Swiss rolls of proximal and distal intestine from ApcMin/Apc+ (+/+) and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (-/-) mice. Both proximal and distal intestine from ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (-/-) mice showed an increase in tumor number. Scale bars: 1 mm.
Copyright This image is from Nam KT, J Clin Invest 2010 Mar;120(3):840-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158733
Associated
Alleles
Symbol Name
ApcMin adenomatosis polyposis coli; multiple intestinal neoplasia
Rab25tm1Jrgo RAB25, member RAS oncogene family; targeted mutation 1, James R Goldenring
Associated
Genotypes
Allelic Composition Genetic Background
ApcMin/Apc+ C57BL/6J-ApcMin
ApcMin/Apc+
Rab25tm1Jrgo/Rab25tm1Jrgo
B6.Cg-Rab25tm1Jrgo ApcMin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory