Molecular Image Detail

Image

Caption

Generation of the Cpeb4^{tm1a(EUCOMM)Wtsi} (Cpeb4^GT) and Cpeb4^{tm1d(EUCOMM)Wtsi} (Cpeb4^deltaE2) alleles. (A) Schematic diagram of Cpeb4 wild-type (WT), Cpeb4 gene trap and Cpeb4 exon 2 deletion alleles. White boxes indicate exons of the gene, and the lines indicate introns. For coding regions of the Cpeb4 WT allele, functional domains of the CPEB4 protein are indicated with amino acid residue numbers on top. NES indicates nuclear export signal; RRM indicates RNA recognition motif; ZF indicates a zinc finger domain. The gene trap cassette contains splice acceptor site (SA) site, lacZ, neo selection marker gene, and the SV40 polyadenylation sequence (pA). FRT and loxP indicate recombinase sites. 2A indicates a self-cleaving protease sequence. PTC indicates premature termination codon introduced due to the deletion of exon 2.

This image is from Shin J, Sci Rep 2016 Jul 06;6():29395, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:236098

Associated
Alleles

Symbol	Name
Cpeb4^{tm1a(EUCOMM)Wtsi}	cytoplasmic polyadenylation element binding protein 4; targeted mutation 1a, Wellcome Trust Sanger Institute
Cpeb4^{tm1a(EUCOMM)Wtsi}	cytoplasmic polyadenylation element binding protein 4; targeted mutation 1a, Wellcome Trust Sanger Institute
Cpeb4^{tm1d(EUCOMM)Wtsi}	cytoplasmic polyadenylation element binding protein 4; targeted mutation 1d, Wellcome Trust Sanger Institute

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