Cpeb4^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cpeb4^{tm1d(EUCOMM)Wtsi}
• Name: cytoplasmic polyadenylation element binding protein 4; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5805966
• Synonyms: Cpeb4^deltaE2
• Gene: Cpeb4 Location: Chr11:31822211-31885634 bp, + strand Genetic Position: Chr11, 18.66 cM
• Alliance: Cpeb4^{tm1d(EUCOMM)Wtsi} page
• IMPC: Cpeb4 gene page

Mutation origin

• Mutant Cell Line: EPD0060_4_E10
• Germline Transmission: Earliest citation of germline transmission: J:236098
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Vector: L1L2_gt0 Mutation details: The L1L2_gt0 cassette was inserted at position 31839292 of Chromosome 11 upstream of the exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 31840308. Cre and Flp-mediated recombination resulted in the deletion of the lacZ/neomycin sequences and the loxP-flanked exon 2. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:236098)

Generation of the Cpeb4^tm1a(EUCOMM)Wtsi and Cpeb4^tm1d(EUCOMM)Wtsi alleles

Expression

In Mice Carrying this Mutation:

4 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpeb4 Mutation: 19 strains or lines available

References

• Original: J:236098 Shin J, et al., Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration. Sci Rep. 2016 Jul 06;6:29395
• All: 7 reference(s)