Phenotype Image Detail

Image

Caption

After fixation of 18 month-old mice animals, 50 mm coronal sections were stained with Thioflavin T to label beta-amyloid plaques. A) Tg(APPswe,PSEN1dE9)85Dbo/0 (Swede) mouse. White arrows indicate plaques in the orbital frontal cortex and anterior olfactory cortex, respectively. B) 18 month-old control mouse without any plaque staining. C) A Z-stack showing a 10 mm diameter plaque, one of the larger ones observed. D) A middle tufted cell of the olfactory bulb showing Tau tangle phenotype in a tested Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/0 (Tau) mouse.

Copyright

This image is from Phillips M, PLoS One 2011;6(5):e19567, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172426

Associated Alleles

Symbol	Name
Mapt^tm1(EGFP)Klt	microtubule-associated protein tau; targeted mutation 1, Kerry Lee Tucker
Tg(APPswe,PSEN1dE9)85Dbo	transgene insertion 85, David R Borchelt
Tg(MAPT)8cPdav	transgene insertion 8c, Peter Davies

Associated Genotypes

Allelic Composition	Genetic Background
Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/0	B6.Cg-Tg(MAPT)8cPdav Mapt^tm1(EGFP)Klt/J
Tg(APPswe,PSEN1dE9)85Dbo/0	B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax