Phenotype Image Detail

Image

Caption

Peyer's Patches (PP) of Ednrb^tm1Nrd/Ednrb^tm1Nrd Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/0 animals are small in size but have normal architecture. (A) Gross photographs of representative PP isolated fromheterozygous and hmozygous mutant animals demonstrating the size difference. Scale bar = 1000 um. (B) H&E staining of PP cross-sections from heterozygous and homozygous animals. Architectural features are preserved in homozygotes. Scale bar = 400 um (applies to B,C,D). (C) IHC of PP cross-sections with CD3labeling T cells. (D) IHC of PP cross-sections with B220 labeling B cells. The spatial distribution of B-cells and T-cells is similar between heterozygotes and homozygotes.

Copyright

This image is from Gosain A, PLoS One 2015;10(6):e0128822, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:233811

Associated Alleles

Symbol	Name
Ednrb^tm1Nrd	endothelin receptor type B; targeted mutation 1, Noah Druckenbrod
Gt(ROSA)26Sor^tm14(CAG-tdTomato)Hze	gene trap ROSA 26, Philippe Soriano; targeted mutation 14, Hongkui Zeng
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch