Phenotype Image Detail

Image

Caption

Conditional ablation of Tbx1 in pharyngeal ectoderm results in fourth pharyngeal arch artery (PAA) aplasia. (A) Typical fourth PAA morphology in a Tbx1^tm2.1Bem/Tbx1^tm2.1Bem (Tbx1^fl/fl) control embryo at E10.5, revealed by intracardiac ink injection. (B) Hypoplasia of the fourth PAA (arrow) in a conditionally heterozygous Tbx1^tm2.1Bem/Tbx1⁺ Tfap2a^tm1(cre)Moon/Tfap2a⁺ (AP2aIRESCre;Tbx1^+/fl) embryo at E10.5. Scale bar: 100 um.

Copyright

This image is from Randall V, J Clin Invest 2009 Nov;119(11):3301-10 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154590

Associated Alleles

Symbol	Name
Tbx1^tm2.1Bem	T-box 1; targeted mutation 2.1, Bernice E Morrow
Tfap2a^tm1(cre)Moon	transcription factor AP-2, alpha; targeted mutation 1, Anne M Moon

Associated Genotypes

Allelic Composition	Genetic Background
Tbx1^tm2.1Bem/Tbx1^+ Tfap2a^tm1(cre)Moon/Tfap2a^+	either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)