Phenotype Image Detail

Image

Caption

Transmission electron microscopic (TEM) analysis of cerebral cortex tissue from 17-18 month Tg(PDGFB-LRRK2*G2019S)340Djmo/0 mice. A-D, Vacuoles with multiple membranes resembling autophagosomes or autophagic vacuoles (indicated by *) are observed within regions enriched in axons and/or synapses (A-C) or within neuronal soma (D). E and F, Clusters of condensed mitochondria within the neuronal soma (indicated by arrows) reminiscent of mitochondria that are undergoing autophagocytosis. Synapses (arrowheads), axons (ax) and normal mitochondria (m) are indicated.

Copyright

This image is from Ramonet D, PLoS One 2011;6(4):e18568, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171645

Associated Alleles

Symbol	Name
Tg(PDGFB-LRRK2*G2019S)340Djmo	transgene insertion 340, Darren Moore

Associated Genotypes

Allelic Composition	Genetic Background
Tg(PDGFB-LRRK2*G2019S)340Djmo/0	involves: C3H/HeJ * C57BL/6J