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Transgene Detail
Symbol: Tg(PDGFB-LRRK2*G2019S)340Djmo
Name: transgene insertion 340, Darren Moore
MGI ID: MGI:4950671
Synonyms: G2019S-LRRK2
Transgene: Tg(PDGFB-LRRK2*G2019S)340Djmo  Location: unknown  
Alliance: Tg(PDGFB-LRRK2*G2019S)340Djmo page
Progressive loss of substantia nigra dopaminergic neurons in Tg(PDGFB-LRRK2*G2019S)340Djmo/0 transgenic mice

Show the 6 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6J x C3H/HeJ)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PDGFB-LRRK2*G2019S)340Djmo expresses 1 gene
Mutation detailsThe G2019S-LRRK2 transgene was designed with a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of a full length human leucine-rich repeat kinase 2 (LRRK2) cDNA. LRRK2 cDNA was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2*G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease. Line 340 was generated. (J:171645)
Schematic of the Tg(PDGFB-LRRK2*G2019S)340Djmo or Tg(PDGFB-LRRK2*R1441C)574Djmo transgene
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:171645 Ramonet D, et al., Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2. PLoS One. 2011;6(4):e18568
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory