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Phenotype Image Detail
Image
Caption Iron accumulates in axons and oliogodendrocyte cell bodies of Ireb2tm1.1Eal/Ireb2tm1.1Eal (Irp2-/-) mice. Increased diaminobenzidine (DAB)-enhanced Perls' iron stain is observed in small cells that have an eccentric nucleus characteristic of oliogodendrocyte morphology and in axons in A) cerebral cortex, B) caudate putamen, C) superior colliculus, D) substantia nigra, and E) cerebellum. Arrows, oligodendrocytes; S, striosomes; wm, white matter; gl, granule layer. Scale bars: 50 um and 500 um.
Copyright This image is from Zumbrennen-Bullough KB, PLoS One 2014;9(6):e98072, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:217335
Associated
Alleles
Symbol Name
Ireb2tm1.1Eal iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold
Associated
Genotypes
Allelic Composition Genetic Background
Ireb2tm1.1Eal/Ireb2tm1.1Eal B6J.129-Ireb2tm1.1Eal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory