Phenotype Image Detail

Image

Caption

Iron accumulates in axons and oliogodendrocyte cell bodies of Ireb2^tm1.1Eal/Ireb2^tm1.1Eal (Irp2^-/-) mice. Increased diaminobenzidine (DAB)-enhanced Perls' iron stain is observed in small cells that have an eccentric nucleus characteristic of oliogodendrocyte morphology and in axons in A) cerebral cortex, B) caudate putamen, C) superior colliculus, D) substantia nigra, and E) cerebellum. Arrows, oligodendrocytes; S, striosomes; wm, white matter; gl, granule layer. Scale bars: 50 um and 500 um.

Copyright

This image is from Zumbrennen-Bullough KB, PLoS One 2014;9(6):e98072, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:217335

Associated Alleles

Symbol	Name
Ireb2^tm1.1Eal	iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold

Associated Genotypes

Allelic Composition	Genetic Background
Ireb2^tm1.1Eal/Ireb2^tm1.1Eal	B6J.129-Ireb2^tm1.1Eal