Phenotype Image Detail

Image

Caption

Presymptomatic adult Fat1^{Gt(KST249)Byg}/Fat1^{Gt(KST249)Byg} Tg(Myl1-lacZ)1Ibdml/0 (Fat1^LacZ/LacZ) mice show selective defects in scapular muscles. (A) Adult mutant mice show visible scapular winging (orange arrow) at stages prior to detectable weight loss (defined as presymptomatic). Pictures (extracted from movies) show a posture in which the mice challenge their shoulder girdle muscles by extending their head as far rostral as possible. At 7 weeks, wasting of the rhomboid muscles can already be detected in presymtomatic mice as they move on a cage grid. Note the large gap (orange arrow) between scapulas (where rhomboids normally maintain scapulas attached to the dorsal spine), not visible in the corresponding position in the wild-type (WT) littermate. (B) At advanced symptomatic stages (30% weight loss, anesthetized mice), there is marked curvature of the spine in the upper back and shoulder area, also visible through X-ray post-mortem imaging.

Copyright

This image is from Caruso N, PLoS Genet 2013 Jun;9(6):e1003550, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199157

Associated Alleles

Symbol	Name
Fat1^Gt(KST249)Byg	FAT atypical cadherin 1; gene trap KST249, BayGenomics
Tg(Myl1-lacZ)1Ibdml	transgene insertion 1, Developmental Biology Institue of Marseilles-Luminy

Associated Genotypes

Allelic Composition	Genetic Background
Fat1^Gt(KST249)Byg/Fat1^Gt(KST249)Byg Tg(Myl1-lacZ)1Ibdml/0	involves: 129P2/OlaHsd