Phenotype Image Detail

Image

Caption

A, representative image of a heterozygous Nmnat2^{Gt(EUCE0262a08)Hmgu}/Nmnat2⁺ (+/gt) pup and a homozygous Nmnat2^{Gt(EUCE0262a08)Hmgu}/Nmnat2^{Gt(EUCE0262a08)Hmgu} (gt/gt) pup just after birth (P0). Homozygous pups died at birth, due to a failure to initiate respiration (their lungs remained uninflated), and showed a distinctive hunched posture. Hunched posture was already evident in E18.5 embryos which showed signs of paralysis. Heterozygous pups and embryos were indistinguishable from wild-types (+/+) in this respect. B, representative bladders dissected from fixed wild-type, heterozygous and homozygous E18.5 embryos. Homozygous E18.5 embryos and P0 pups have massively swollen bladders. In contrast, heterozygous E18.5 embryos and P0 pups have normal bladders.

Copyright

This image is from Hicks AN, PLoS One 2012;7(10):e47869, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192196

Associated Alleles

Symbol	Name
Nmnat2^Gt(EUCE0262a08)Hmgu	nicotinamide nucleotide adenylyltransferase 2; gene trap EUCE0262a08, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Nmnat2^Gt(EUCE0262a08)Hmgu/Nmnat2^Gt(EUCE0262a08)Hmgu	involves: 129P2/OlaHsd * C57BL/6J