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Phenotype Image Detail
Caption Representative images are shown for at least three embryos of each genotype. (a, b) A control embryo (in this case, heterozygous Fras1tm1.1Pjsc mice (Fras1fl/+)) and dissected viscera at Day 14 of gestation. Note two normal kidneys (k) and adrenal glands (a), and the bladder (b). * in (a) marks the ventrally-protruding midgut and umbilical vessels (i.e., not a pathological hemorrhage). (c, d) FRAS1 immunohistochemistry in a control embryo shows linear immunostaining at the epidermal/dermal junction (brown line, arrowed in c) and in the renal primordium (arrowed in d); ub is the ureteric bud which has branched from the mesonephric duct, lying above it. (e, f) Whole mounts of a Fras1tm1.2Pjsc/Fras1tm1.2Pjsc (Fras1D2/D2) embryo (e) and dissected viscera at day 14 of gestation. Note the hemorrhagic blister over the eye. The small box and enlarged box show hemorrhage over the limb. Note that the adrenals (a) and bladder (b) are present but there are no kidneys, with 1 marking their expected location. (g, h) Immunohistochemistry in a Fras1tm1.2Pjsc/Fras1tm1.2Pjsc embryo. In the photomicrograph of skin (g), note the large blister on the left-hand side of the frame and the lack of FRAS1 expression at the epidermal/dermal border (arrowed). Basal FRAS1 immunostaining is absent in primordial renal epithelia (h; arrow points to the ureteric bud (u) and the mesonephric duct region). In the histology images, all nuclei are stained blue with hematoxylin. Scale bars 50 um.
Copyright This image is from Pitera JE, Genesis 2012 Dec;50(12):892-8, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:190659
Symbol Name
Fras1tm1.2Pjsc Fraser extracellular matrix complex subunit 1; targeted mutation 1.2, Peter J Scambler
Allelic Composition Genetic Background
Fras1tm1.2Pjsc/Fras1tm1.2Pjsc involves: C57BL/6 * FVB/N * SJL

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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